Diagnostic Index Of Blood Coagulation Function


Wolemba: Wolowa m'malo   

Matenda a coagulation a magazi amalembedwa nthawi zonse ndi madokotala.Odwala omwe ali ndi matenda ena kapena omwe akumwa mankhwala a anticoagulant ayenera kuyang'anira kuchuluka kwa magazi.Koma kodi manambala ochuluka chotere amatanthauza chiyani?Ndi zizindikiro ziti zomwe ziyenera kuyang'aniridwa kuchipatala pa matenda osiyanasiyana?

Ma coagulation function test indexes akuphatikizapo prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), clotting time (CT) and International normalized ratio (INR), etc., zinthu zingapo zitha kukhala osankhidwa kuti apange phukusi, lomwe limatchedwa coagulation X chinthu.Chifukwa cha njira zosiyanasiyana zodziwira zomwe zimagwiritsidwa ntchito ndi zipatala zosiyanasiyana, mafotokozedwe amasiyananso.

PT-prothrombin nthawi

PT imatanthawuza kuwonjezera minofu (TF kapena minofu thromboplastin) ndi Ca2 + ku plasma kuti ayambe kutuluka kunja kwa coagulation system ndikuwona nthawi ya coagulation ya plasma.PT ndi amodzi mwa mayeso omwe amagwiritsidwa ntchito kwambiri pakuwunika kwachipatala kuti awone momwe njira ya extrinsic coagulation imagwirira ntchito.Mtengo wodziwika bwino ndi 10 mpaka 14 masekondi.

APTT - activated partial thromboplastin nthawi

APTT ndiyowonjezera XII factor activator, Ca2+, phospholipid ku plasma kuti ayambitse njira ya plasma endogenous coagulation, ndikuwona nthawi ya plasma coagulation.APTT ndi amodzi mwa mayeso omwe amagwiritsidwa ntchito kwambiri m'machitidwe azachipatala kuti awone momwe njira yolumikizira mkati imagwirira ntchito.Mtengo wodziwika bwino ndi 32 mpaka 43 masekondi.

INR - International Normalized Ratio

INR ndi mphamvu ya ISI ya chiŵerengero cha PT cha wodwala woyesedwa ndi PT ya kayendetsedwe kabwinobwino (ISI ndi chidziwitso chapadziko lonse lapansi, ndipo reagent imayesedwa ndi wopanga ikachoka kufakitale).Madzi a m'magazi omwewo adayesedwa ndi ma reagents osiyanasiyana a ISI m'ma laboratories osiyanasiyana, ndipo zotsatira zamtengo wapatali za PT zinali zosiyana kwambiri, koma miyeso ya INR yoyezedwa inali yofanana, zomwe zidapangitsa kuti zotsatira zake zifanane.Mtengo wodziwika bwino ndi 0.9 mpaka 1.1.

TT-thrombin nthawi

TT ndiko kuwonjezera kwa muyezo wa thrombin ku plasma kuti azindikire gawo lachitatu la coagulation, kuwonetsa kuchuluka kwa fibrinogen mu plasma ndi kuchuluka kwa zinthu ngati heparin mu plasma.Mtengo wodziwika bwino ndi 16 mpaka 18 masekondi.

FIB-fibrinogen

FIB ndiyowonjezera kuchuluka kwa thrombin ku plasma yoyesedwa kuti asinthe fibrinogen mu plasma kukhala fibrin, ndikuwerengera zomwe zili mu fibrinogen kudzera mu mfundo ya turbidimetric.Mtengo wodziwika bwino ndi 2 mpaka 4 g/L.

FDP-plasma fibrin degradation product

FDP ndi liwu lodziwika bwino lazinthu zowonongeka zomwe zimapangidwa pambuyo pa kuwonongeka kwa fibrin kapena fibrinogen pansi pa zochita za plasmin zomwe zimapangidwa panthawi ya hyperfibrinolysis.Mtengo wodziwika bwino ndi 1 mpaka 5 mg/L.

CT-coagulation nthawi

CT imatanthawuza nthawi yomwe magazi amachoka m'mitsempha yamagazi ndikumangirira mu vitro.Imatsimikizira makamaka ngati zinthu zosiyanasiyana za coagulation mu intrinsic coagulation njira zikusowa, kaya ntchito yawo ndi yachibadwa, kapena ngati pali kuwonjezeka kwa zinthu za anticoagulant.