I-APTT imele isikhathi se-thromboplastin esingaphelele esisebenzayo, esibhekisela esikhathini esidingekayo ukuze kufakwe i-thromboplastin engaphelele ku-plasma evivinyiwe futhi kugcinwe isikhathi esidingekayo ukuze kuhlanganiswe i-plasma. I-APTT iyisivivinyo sokuhlola esibucayi nesisetshenziswa kakhulu sokunquma uhlelo lokugoba lwe-endogenous. Ububanzi obujwayelekile buyimizuzwana engama-31-43, kanye nemizuzwana eyi-10 ngaphezu kokulawula okujwayelekile kunokubaluleka kwezokwelapha. Ngenxa yomehluko phakathi kwabantu, uma izinga lokufinyela kwe-APTT lincane kakhulu, kungase kube yinto evamile, futhi asikho isidingo sokwesaba ngokweqile, futhi ukuhlolwa kabusha okuvamile kwanele. Uma uzizwa ungaphilile, bona udokotela ngesikhathi.

Ukuncipha kwe-APTT kubonisa ukuthi igazi lisesimweni sokujiya ngokweqile, okuyinto evamile ezifweni zenhliziyo nemithambo yegazi, njenge-cerebral thrombosis kanye nesifo senhliziyo.

1. I-thrombosis yobuchopho

Iziguli ezine-APTT emfushane kakhulu zinamathuba amaningi okuthuthukisa i-cerebral thrombosis, okuyinto evamile ezifweni ezihlobene nokwanda kwegazi okubangelwa izinguquko ezingxenyeni zegazi, njenge-hyperlipidemia. Ngalesi sikhathi, uma izinga le-cerebral thrombosis lincane kakhulu, kuzovela izimpawu zokunganeli kwegazi ebuchosheni, njengesiyezi, ikhanda elibuhlungu, isicanucanu, nokuhlanza. Uma izinga le-cerebral thrombosis libi ngokwanele ukubangela ischemia enzima ye-cerebral parenchymal, kuzovela izimpawu zomtholampilo ezifana nokungasebenzi kahle kokunyakaza kwezitho, ukukhubazeka kokukhuluma, kanye nokungakwazi ukuzibamba. Ezigulini ezine-cerebral thrombosis ebukhali, ukuhogela umoya-mpilo kanye nokusekelwa komoya-mpilo kuvame ukusetshenziselwa ukwandisa ukuhlinzekwa komoya-mpilo. Lapho izimpawu zesiguli zisongela ukuphila, i-thrombolysis esebenzayo noma ukuhlinzwa kokungenelela kufanele kwenziwe ukuvula imithambo yegazi ngokushesha okukhulu. Ngemva kokuba izimpawu ezibucayi ze-cerebral thrombosis sezinciphile futhi zilawulwa, isiguli kufanele siqhubeke sinamathele emikhubeni emihle yokuphila futhi sithathe imithi yesikhathi eside ngaphansi kokuqondiswa odokotela. Kunconywa ukudla ukudla okunosawoti omncane namafutha amancane ngesikhathi sokululama, ukudla imifino nezithelo eziningi, ukugwema ukudla ukudla okune-sodium ephezulu njengebhekoni, ama-pickle, ukudla okusemathinini, njll., kanye nokugwema ukubhema notshwala. Vivinya umzimba ngokulinganisela uma isimo sakho somzimba sivuma.

2. Isifo senhliziyo

Ukufinyezwa kwe-APTT kubonisa ukuthi isiguli singase sibe nesifo senhliziyo, esivame ukubangelwa ukuqina kwegazi lenhliziyo okuholela ekuqineni kwegazi noma ekuvalekeni kwe-lumen yemithambo yegazi, okuholela ekushayweni kwegazi okufana ne-myocardial ischemia, i-hypoxia, kanye ne-necrosis. Uma izinga lokuvaleka kwemithambo yenhliziyo liphezulu, isiguli singase singabi nazimpawu zomtholampilo ezisobala esimweni sokuphumula, noma singase sizizwe singakhululekile njengokuqina kwesifuba kanye nobuhlungu besifuba ngemva kwemisebenzi. Uma izinga lokuvaleka kwemithambo yenhliziyo libi kakhulu, ingozi yokuhlaselwa yinhliziyo iyanda. Iziguli zingase zizwe ubuhlungu besifuba, ukuqina kwesifuba, kanye nokuphefumula okunzima lapho ziphumule noma zijabule ngokomzwelo. Ubuhlungu bungasakazeka kwezinye izingxenye zomzimba futhi buqhubeke ngaphandle kokukhululeka. Ezigulini ezinesifo senhliziyo esibi kakhulu, ngemuva kokuphathwa kwe-nitroglycerin noma i-isosorbide dinitrate ngaphansi kwezilimi ezimbili, bona udokotela ngokushesha, futhi udokotela uhlola ukuthi ngabe ukufakelwa kwe-stent yenhliziyo noma i-thrombolysis kuyadingeka ngokushesha. Ngemva kwesigaba esibi kakhulu, kudingeka ukwelashwa kwesikhathi eside kwe-antiplatelet kanye ne-anticoagulant. Ngemva kokuphuma esibhedlela, isiguli kufanele sidle ukudla okunosawoti omncane nokunamafutha amancane, siyeke ukubhema nokuphuza, sivivinye umzimba ngendlela efanele, futhi siqaphele ukuphumula.