Ngwa ụlọ ọgwụ nke coagulation ọbara na ọrịa obi na ọrịa cerebrovascular (1)


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1. Clinical ngwa nke ọbara coagulation oru ngo na obi na cerebrovascular ọrịa

N'ụwa niile, ọnụ ọgụgụ ndị mmadụ na-arịa ọrịa obi na akwara ozi buru ibu, ọ na-egosikwa mmụba na-abawanye kwa afọ.Na omume ụlọ ọgwụ, ndị ọrịa nkịtị na-enwe obere oge mmalite ma na-esonyere ya na hemorrhage cerebral, nke na-emetụta prognosis ma na-eyi ndụ nchekwa ndụ nke ndị ọrịa egwu.
Enwere ọtụtụ ọrịa nke ọrịa obi na akwara ozi, na ihe ndị na-emetụta ha dịkwa mgbagwoju anya.Site na mmụba na-aga n'ihu nke nyocha ụlọ ọgwụ na coagulation, a na-achọpụta na na ọrịa obi na ọrịa cerebrovascular, a pụkwara iji ihe ndị na-akpata coagulation mee ihe dị ka ihe ize ndụ maka ọrịa a.Ọmụmụ ihe ọmụmụ ụlọ ọgwụ egosila na ụzọ ụzọ coagulation nke mpụga na nke dị n'ime nke ndị ọrịa dị otú ahụ ga-enwe mmetụta na nyocha, nyocha na prognosis nke ọrịa ndị dị otú ahụ.Ya mere, nyocha zuru oke nke ihe ize ndụ coagulation nke ndị ọrịa dị oke mkpa maka ndị ọrịa nwere ọrịa obi na ọrịa ụbụrụ.mkpa.

2. Kedu ihe kpatara ndị ọrịa nwere obi na ọrịa cerebrovascular kwesịrị ịṅa ntị na ihe ngosi coagulation

Ọrịa obi na akwara ozi bụ ọrịa ndị na-etinye ahụ ike na ndụ mmadụ n'ihe egwu nke ukwuu, na-enwe oke ọnwụ na oke nkwarụ.
Site na nchọpụta nke ọrụ coagulation na ndị ọrịa nwere ọrịa obi na ọrịa cerebrovascular, ọ ga-ekwe omume ịchọpụta ma onye ọrịa ahụ nwere ọbara ọgbụgba na ihe ize ndụ nke thrombosis venous;N'ime usoro ọgwụgwọ ọgwụ mgbochi ọrịa na-esote, enwere ike nyochaa mmetụta mgbochi yana enwere ike iduzi ọgwụ ụlọ ọgwụ iji zere ọbara ọgbụgba.

1).Ndị ọrịa strok

Ọrịa strok nke cardioembolic bụ ọrịa strok nke ischemic kpatara site na mbelata cardiogenic emboli na ime ka akwara ụbụrụ kwekọrọ na ya, na-aza 14% ruo 30% nke ọrịa strok ischemic niile.N'ime ha, ọrịa strok metụtara fibrillation na-akpata ihe karịrị 79% nke ọrịa strok obi obi, na ọrịa strok cardioembolic dị njọ karị, ekwesịrị ka a mata ya n'oge ma tinye aka na ya.Iji nyochaa ihe ize ndụ thrombosis na ọgwụgwọ anticoagulation nke ndị ọrịa, na ọgwụgwọ ọgwụgwọ ọgwụ mgbochi mkpa ụlọ ọgwụ kwesịrị iji ihe ngosi coagulation iji nyochaa mmetụta anticoagulation na ọgwụ mgbochi kpọmkwem iji gbochie ọbara ọgbụgba.

Ihe ize ndụ kachasị na ndị ọrịa nwere fibrillation atrial bụ thrombosis arterial, karịsịa ụbụrụ ụbụrụ.Ndụmọdụ mgbochi mgbochi mkpali maka infarction cerebral nke abụọ na fibrillation atrial:
1. A naghị atụ aro iji ọgwụ mgbochi ọrịa eme ihe ozugbo maka ndị ọrịa nwere nnukwu ọrịa ụbụrụ ụbụrụ.
2. N'ime ndị ọrịa na-agwọ ọrịa thrombolysis, a naghị atụ aro ka iji ọgwụ mgbochi n'ime awa 24.
3. Ọ bụrụ na enweghị ihe mgbochi dịka ọbara ọgbụgba, ọrịa imeju na akụrụ siri ike, ọbara mgbali elu>180/100mmHg, wdg, enwere ike were ọnọdụ ndị a họrọ iji ọgwụ mgbochi ọrịa:
(1) Ndị na-arịa ọrịa obi (dịka valvụ artificial, fibrillation atrial, infarction myocardial with mural thrombus, ekpe atrial thrombosis, wdg) na-enwekarị ọrịa strok ugboro ugboro.
(2) Ndị ọrịa nwere ọrịa strok na-esonyere ụkọ protein C, protein S, protein C resistance na ndị ọzọ na-arịa ọrịa thromboprone;ndị ọrịa nwere mgbaàmà extracranial dissecting aneurysm;ndị ọrịa nwere intracranial na intracranial artery stenosis.
(3) Ndị ọrịa na-ehi ụra na ụbụrụ ụbụrụ nwere ike iji heparin dị ala ma ọ bụ LMWH kwekọrọ na ya iji gbochie thrombosis miri emi na pulmonary embolism.

2).Uru nke nlekota ihe nleba anya coagulation mgbe a na-eji ọgwụ anticoagulant

• PT: Ọrụ INR nke ụlọ nyocha dị mma ma enwere ike iji ya duzie nhazi dose nke warfarin;nyochaa ihe ize ndụ ọbara ọgbụgba nke rivaroxaban na edoxaban.
• APTT: Enwere ike iji chọpụta ịdị irè na nchekwa nke heparin na-adịghị emebi emebi na iji chọpụta ihe ize ndụ ọbara ọgbụgba nke dabigatran.
• TT: Sensitive to dabigatran, eji iji nyochaa residual dabigatran n'ime ọbara.
• D-Dimer / FDP: Enwere ike iji ya nyochaa mmetụta ọgwụgwọ nke ọgwụ anticoagulant dị ka warfarin na heparin;na iji nyochaa mmetụta ọgwụgwọ nke ọgwụ thrombolytic dị ka urokinase, streptokinase, na alteplase.
• AT-III: Enwere ike iji ya na-eduzi mmetụta ọgwụ nke heparin, heparin dị arọ dị ala, na fondaparinux, na igosi ma ọ dị mkpa ịgbanwe ọgwụ mgbochi ọrịa na-agwọ ọrịa.

3).Mgbochi mgbochi tupu na mgbe cardioversion nke atrial fibrillation

Enwere ihe ize ndụ nke thromboembolism n'oge cardioversion of atrial fibrillation, na ọgwụgwọ ọgwụ mgbochi kwesịrị ekwesị nwere ike ibelata ohere nke thromboembolism.Maka ndị ọrịa na-adịghị akwụ ụgwọ hemodynamically nwere fibrillation atrial chọrọ cardioversion ngwa ngwa, mmalite nke ọgwụ mgbochi ọrịa ekwesịghị igbu oge cardioversion.Ọ bụrụ na enweghị ihe mgbochi, a ga-eji heparin ma ọ bụ heparin dị arọ ma ọ bụ NOAC mee ihe ozugbo enwere ike, a ga-emekwa cardioversion n'otu oge.