Isizathu esisisiseko

1. Ukulimala kwentliziyo kunye nemithambo yegazi
Ukulimala kweeseli zemithambo yegazi yeyona nto ibalulekileyo neqhelekileyo yokwakheka kwe-thrombus, kwaye kuxhaphake kakhulu kwi-rheumatic and infective endocarditis, izilonda ze-atherosclerotic plaque ezinzima, iindawo zokwenzakala kwe-arteriovenous trauma okanye inflammatory, njl. Kukwakho ne-hypoxia, shock, sepsis kunye ne-bacterial endotoxins ezibangela uluhlu olubanzi lwezifo ze-endogenous kuwo wonke umzimba.
Emva kokwenzakala kwesikhumba, i-collagen ephantsi kwe-endothelium ivuselela inkqubo yokujiya, ibangela ukujiya kwemithambo yegazi esasazekileyo, kwaye i-thrombus iyenzeka kwi-microcirculation yomzimba wonke.

2. Ukuhamba kwegazi okungaqhelekanga
Ibhekisa ikakhulu ekunciphiseni ukuhamba kwegazi kunye nokuveliswa kwee-eddies ekuhambeni kwegazi, njl.njl., kwaye izinto ezisebenza ngokuxinana kwegazi kunye ne-thrombin zifikelela kuxinzelelo olufunekayo ukuze kuxinane kwindawo yasekuhlaleni, nto leyo enceda ekwakhekeni kwe-thrombus. Phakathi kwazo, imithambo ichaphazeleka kakhulu yi-thrombus, nto leyo exhaphake kakhulu kwizigulana ezinesifo sentliziyo, izifo ezingapheliyo kunye nokuphumla ebhedini emva kotyando. Ukongeza, ukuhamba kwegazi entliziyweni nakwimithambo yegazi kuyakhawuleza, kwaye akulula ukwenza i-thrombus. Nangona kunjalo, xa ukuhamba kwegazi kwi-atrium yasekhohlo, i-aneurysm, okanye isebe lomthambo wegazi licotha kwaye kwenzeka i-eddy current ngexesha le-mitral valve stenosis, ikwachaphazeleka yi-thrombosis.

3. Ukwanda kokujiya kwegazi
Ngokubanzi, iiplatelets kunye nezinto ezibangela ukujiya kwegazi ziyanda, okanye umsebenzi wenkqubo ye-fibrinolytic uyancipha, nto leyo ekhokelela kwimeko yokujiya kwegazi egazini, exhaphake kakhulu kwiimeko ze-hypercoagulable zelifa kunye nezo zifunyenweyo.

4. Imeko yokuqhekeka kwegazi ngenxa yelifa
Inxulumene neziphene ze-coagulation factor defects ze-gene, iziphene zokuzalwa zeproteni C kunye neproteni S, njl. Phakathi kwazo, eyona nguqu ye-gene ye-factor V eqhelekileyo, izinga lokuguquka kwale gene linokufikelela kwi-60% kwizigulane ezine-deep vein thrombosis ephindaphindayo.

5. Imeko yokuba ne-hypercoagulable efunyenweyo
Idla ngokubonakala kumhlaza wepancreatic, umhlaza wemiphunga, umhlaza webele, umhlaza weprostate, umhlaza wesisu kunye nezinye iithumba ezinobungozi ezisasazeke kakhulu, ezibangelwa kukukhululwa kwezinto ezibangela ukugabha kwegazi ziiseli zomhlaza; inokwenzeka nakwintlungu enkulu, ukutsha okukhulu, utyando olukhulu okanye emva kokuzalwa Kwimeko yokulahleka kwegazi okukhulu, nakwiimeko ezifana noxinzelelo lwegazi lokukhulelwa, i-hyperlipidemia, i-coronary atherosclerosis, ukutshaya, kunye nokutyeba kakhulu.