Chifukwa chachikulu

1. Kuvulala kwa mtima ndi mitsempha yamagazi
Kuvulala kwa maselo a mitsempha yamagazi ndiye chifukwa chachikulu komanso chofala kwambiri cha kupangika kwa magazi m'mitsempha, ndipo kumachitika kawirikawiri mu matenda a rheumatic ndi infective endocarditis, zilonda zazikulu za atherosclerotic plaque, malo ovulala opweteka kapena otupa a arteriovenous, ndi zina zotero. Palinso hypoxia, shock, sepsis ndi mabakiteriya omwe amayambitsa matenda osiyanasiyana amkati mwa thupi lonse.
Pambuyo pa kuvulala kwa khungu, kolajeni yomwe ili pansi pa endothelium imayambitsa njira yolumikizirana, zomwe zimapangitsa kuti magazi azigawanika m'mitsempha yamagazi, ndipo magazi amatuluka m'magazi m'thupi lonse.

2. Kuyenda kwa magazi kosazolowereka
Makamaka amatanthauza kuchepa kwa kuyenda kwa magazi ndi kupanga ma eddies mu kuyenda kwa magazi, ndi zina zotero, ndipo zinthu zolimbitsa thupi zomwe zimayambitsidwa ndi thrombin zimafika pamlingo wofunikira kuti magazi azigwira ntchito m'dera lanu, zomwe zimathandiza kuti magazi azigwira ntchito. Pakati pawo, mitsempha yamagazi imakhala ndi thrombus, zomwe zimachitika kwambiri kwa odwala omwe ali ndi vuto la mtima, matenda osatha komanso ogona pambuyo pa opaleshoni. Kuphatikiza apo, kuyenda kwa magazi mumtima ndi m'mitsempha yamagazi kumachitika mwachangu, ndipo sikophweka kupanga thrombus. Komabe, pamene kuyenda kwa magazi mu atrium yakumanzere, aneurysm, kapena nthambi ya mtsempha wamagazi kuli pang'onopang'ono ndipo eddy current imachitika panthawi ya mitral valve stenosis, imakhalanso ndi thrombosis.

3. Kuchuluka kwa magazi oundana
Kawirikawiri, ma platelet ndi zinthu zotsekeka m'magazi zimawonjezeka, kapena ntchito ya dongosolo la fibrinolytic imachepa, zomwe zimapangitsa kuti magazi azitsekeka kwambiri, zomwe zimachitika kwambiri m'magazi omwe ali ndi matenda a hypercoagulable.

4. Chibadwa chodwala matenda oopsa a hypercoagulability
Izi zikugwirizana ndi zofooka za coagulation factor, zofooka zobadwa nazo za protein C ndi protein S, ndi zina zotero. Pakati pawo, kusintha kwa majini a factor V komwe kumafala kwambiri, kuchuluka kwa kusintha kwa jini iyi kumatha kufika 60% mwa odwala omwe ali ndi thrombosis ya mitsempha yozama.

5. Mkhalidwe woti magazi azitha kutsekeka
Kawirikawiri imapezeka mu khansa ya kapamba, khansa ya m'mapapo, khansa ya m'mawere, khansa ya prostate, khansa ya m'mimba ndi zotupa zina zotupa kwambiri, zomwe zimayambitsidwa ndi kutulutsidwa kwa zinthu zoyambitsa magazi ndi maselo a khansa; imathanso kuchitika m'matenda oopsa, kupsa kwambiri, opaleshoni yayikulu kapena pambuyo pobereka. Ngati magazi atayika kwambiri, komanso m'mikhalidwe monga kuthamanga kwa magazi m'mimba, kuchuluka kwa mafuta m'thupi, matenda a mtima, kusuta fodya, ndi kunenepa kwambiri.