Isi ihe kpatara ya

1. Mmerụ ahụ endothelial obi na akwara obi
Mmerụ ahụ nke mkpụrụ ndụ akwara bụ ihe kachasị mkpa na nke a na-ahụkarị nke na-akpata thrombus, ọ na-abụkarịkwa na rheumatic na infective endocarditis, nnukwu ọnya atherosclerotic plaque, traumatic ma ọ bụ inflammatory arteriovenous meninges, wdg. E nwekwara hypoxia, shock, sepsis na bacterial endotoxins nke na-akpata ọtụtụ ọrịa endogenous n'ahụ niile.
Mgbe akpụkpọ ahụ merụrụ ahụ, collagen dị n'okpuru endothelium na-eme ka usoro coagulation rụọ ọrụ, na-eme ka coagulation gbasaa n'ime akwara, thrombus na-etolitekwa na microcirculation nke ahụ dum.

2. Ọbara na-asọfe nke ọma
Ọ na-ezo aka na mbelata ọbara na mmepụta nke eddies na ọbara, wdg., ihe ndị na-eme ka coagulation na thrombin rụọ ọrụ na-eru oke achọrọ maka coagulation na mpaghara ahụ, nke na-akwalite mmepụta nke thrombus. N'ime ha, akwara na-enwekarị thrombus, nke a na-ahụkarị na ndị ọrịa nwere nkụda obi, ọrịa na-adịghị ala ala na ezumike akwa mgbe a wachara ahụ. Na mgbakwunye, ọbara na-eru ngwa ngwa n'obi na akwara na-adị ngwa ngwa, ọ dịghịkwa mfe ịmepụta thrombus. Agbanyeghị, mgbe ọbara na-eru nwayọ na atrium aka ekpe, aneurysm, ma ọ bụ alaka nke arịa ọbara na-adị nwayọ ma eddy current na-eme n'oge mitral valve stenosis, ọ na-enwekwa thrombosis.

3. Mmụba nke ọbara coagulation
N'ozuzu, platelet na ihe ndị na-akpata coagulation n'ọbara na-amụba, ma ọ bụ ọrụ nke sistemu fibrinolytic na-ebelata, na-eduga na ọnọdụ coagulation n'ọbara, nke a na-ahụkarị na steeti nketa na nke enwetara hypercoagulation.

4. Ọnọdụ nketa nke nwere ike ịkpalite coagulation
Ọ metụtara ntụpọ coagulation nke ihe nketa, ntụpọ protein C na protein S n'ime nwa ebu n'afọ, wdg. N'ime ha, mgbanwe mkpụrụ ndụ ihe nketa V kachasị, ọnụego mgbanwe nke mkpụrụ ndụ ihe nketa a nwere ike iru 60% na ndị ọrịa nwere thrombosis miri emi nke akwara.

5. Ọnọdụ hypercoagulable enwetara
A na-ahụkarị ya na kansa pancreatic, kansa akpa ume, kansa ara, kansa prostate, kansa afọ na etuto ọjọọ ndị ọzọ dị oke njọ, nke mkpụrụ ndụ kansa na-ewepụta ihe ndị na-eme ka coagulant dị n'ahụ; ọ nwekwara ike ime na nnukwu mmerụ ahụ, nnukwu ọkụ, nnukwu ịwa ahụ ma ọ bụ mgbe a mụsịrị nwa ma ọ bụrụ na ọbara agbapụta nke ukwuu, yana n'ọnọdụ dịka ọbara mgbali elu n'afọ ime, hyperlipidemia, atherosclerosis akwara obi, ise siga, na oke ibu.