Qhov laj thawj tseem ceeb

1. Kev raug mob ntawm cov hlab ntsha hauv lub plawv
Kev raug mob ntawm cov hlwb endothelial ntawm cov hlab ntsha yog qhov tseem ceeb tshaj plaws thiab feem ntau ua rau muaj thrombus, thiab nws feem ntau tshwm sim hauv rheumatic thiab infective endocarditis, mob hnyav atherosclerotic plaque ulcers, traumatic lossis inflammatory arteriovenous raug mob, thiab lwm yam. Kuj tseem muaj hypoxia, shock, sepsis thiab bacterial endotoxins uas ua rau ntau yam kab mob endogenous thoob plaws lub cev.
Tom qab raug mob ntawm daim tawv nqaij, cov collagen nyob rau hauv endothelium ua rau cov txheej txheem coagulation ua haujlwm, ua rau muaj kev sib kis ntawm cov hlab ntsha hauv lub cev, thiab cov ntshav txhaws hauv cov ntshav ntawm tag nrho lub cev.

2. Cov ntshav ntws tsis zoo
Nws feem ntau yog hais txog qhov qeeb ntawm cov ntshav ntws thiab lub cim ntawm eddies hauv cov ntshav ntws, thiab lwm yam, thiab cov yam ntxwv coagulation thiab thrombin ncav cuag qhov concentration uas xav tau rau coagulation hauv thaj chaw, uas yog qhov zoo rau kev tsim cov thrombus. Ntawm lawv, cov leeg nqaij muaj feem ntau rau thrombus, uas yog ntau dua rau cov neeg mob uas muaj mob plawv tsis ua haujlwm, mob ntev thiab pw tom qab phais. Tsis tas li ntawd, cov ntshav ntws hauv lub plawv thiab cov hlab ntsha yog ceev, thiab nws tsis yooj yim rau kev tsim thrombus. Txawm li cas los xij, thaum cov ntshav ntws hauv sab laug atrium, aneurysm, lossis ceg ntawm cov hlab ntsha qeeb thiab eddy tam sim no tshwm sim thaum lub sijhawm mitral valve stenosis, nws kuj yog feem ntau rau thrombosis.

3. Ua kom cov ntshav khov ntxiv
Feem ntau, cov platelets thiab cov coagulation factors hauv cov ntshav nce ntxiv, lossis cov haujlwm ntawm lub fibrinolytic system txo qis, ua rau muaj hypercoagulable hauv cov ntshav, uas feem ntau tshwm sim hauv cov xwm txheej hypercoagulable uas tau los ntawm noob caj noob ces thiab tau txais.

4. Lub xeev hypercoagulable los ntawm noob caj noob ces
Nws muaj feem cuam tshuam nrog cov teeb meem coagulation factor uas los ntawm noob caj noob ces, cov teeb meem protein C thiab protein S uas los ntawm noob caj noob ces, thiab lwm yam. Ntawm lawv, qhov feem ntau yog qhov hloov pauv ntawm cov noob caj noob ces V, qhov kev hloov pauv ntawm cov noob caj noob ces no tuaj yeem ncav cuag 60% rau cov neeg mob uas muaj cov hlab ntsha tob rov qab los.

5. Tau txais lub xeev hypercoagulable
Feem ntau pom muaj mob qog nqaij hlav pancreatic, mob qog nqaij hlav ntsws, mob qog nqaij hlav mis, mob qog nqaij hlav prostate, mob qog nqaij hlav plab thiab lwm yam mob qog nqaij hlav loj heev uas kis mus rau lwm qhov chaw, uas yog los ntawm kev tso tawm cov tshuaj procoagulant los ntawm cov hlwb qog nqaij hlav; nws kuj tseem tuaj yeem tshwm sim thaum raug mob hnyav, kub hnyiab ntau, phais loj lossis tom qab yug menyuam. Yog tias muaj ntshav ntau, thiab thaum muaj mob ntshav siab thaum cev xeeb tub, ntshav lipid ntau, mob plawv atherosclerosis, haus luam yeeb, thiab rog dhau.