Kumu kumu

1. ʻEha endothelial cardiovascular
ʻO ka hōʻeha ʻana o nā cell endothelial vascular ke kumu nui a maʻamau o ka hoʻokumu ʻia ʻana o thrombus, a ʻoi aku ka maʻamau i ka rheumatic a me ka infective endocarditis, nā ʻeha plaque atherosclerotic koʻikoʻi, nā wahi hōʻeha arteriovenous traumatic a inflammatory paha, a pēlā aku. Aia pū kekahi hypoxia, shock, sepsis a me nā endotoxins bacteria e hoʻoulu ai i nā ʻano maʻi endogenous like ʻole ma ke kino.
Ma hope o ka hōʻeha ʻana o ka ʻili, hoʻāla ka collagen ma lalo o ka endothelium i ke kaʻina hana coagulation, e hana ana i ka disseminated intravascular coagulation, a hoʻokumu ʻia nā thrombus i ka microcirculation o ke kino holoʻokoʻa.

2. Ke kahe koko maʻamau ʻole
ʻO ke kumu nui, ʻo ia ka lohi o ke kahe koko a me ka hana ʻana o nā eddies i ke kahe koko, a pēlā aku, a hiki i nā mea coagulation i hoʻāla ʻia a me ka thrombin i ka nui e pono ai no ka coagulation ma kahi kūloko, kahi e kūpono ai i ka hoʻokumu ʻia ʻana o thrombus. I waena o lākou, ʻoi aku ka maʻalahi o nā veins i ka thrombus, ʻoi aku ka maʻamau i nā poʻe maʻi me ka puʻuwai puʻuwai, ka maʻi mau a me ka hoʻomaha moe postoperative. Eia kekahi, wikiwiki ke kahe koko i loko o ka puʻuwai a me nā aʻa, a ʻaʻole maʻalahi ke hana i ka thrombus. Eia naʻe, i ka wā e lohi ai ke kahe koko ma ka atrium hema, aneurysm, a i ʻole ka lālā o ke kīʻaha koko a hana ʻia ke au eddy i ka wā o ka mitral valve stenosis, hiki nō hoʻi ke thrombosis.

3. Hoʻonui ʻia ke kāpili ʻana o ke koko
Ma keʻano laulā, hoʻonui ʻia nā platelets a me nā mea coagulation i loko o ke koko, a i ʻole e emi ana ka hana o ka ʻōnaehana fibrinolytic, e alakaʻi ana i kahi kūlana hypercoagulable i loko o ke koko, ʻoi aku ka maʻamau i nā kūlana hypercoagulable hoʻoilina a loaʻa.

4. Ke kūlana hypercoagulable hoʻoilina
He pili ia i nā kīnā coagulation hoʻoilina, nā kīnā congenital o ka protein C a me ka protein S, a pēlā aku. I waena o lākou, ʻo ka mutation gene factor V maʻamau ka mea maʻamau, hiki i ka mutation rate o kēia gene ke hiki i ka 60% i nā poʻe maʻi me ka thrombosis vein hohonu hou.

5. Loaʻa ke kūlana hypercoagulable
ʻIke pinepine ʻia i ke kanesa pancreatic, ke kanesa māmā, ke kanesa umauma, ke kanesa prostate, ke kanesa ʻōpū a me nā ʻōpū malignant holomua metastatic ʻē aʻe, i hoʻokumu ʻia e ka hoʻokuʻu ʻana o nā mea procoagulant e nā cell cancer; hiki ke hana ia i ka trauma koʻikoʻi, nā kuni nui, ke ʻoki kino nui a i ʻole postpartum i ka hanana o ke kahe koko nui, a i nā kūlana e like me ke hypertension gestational, hyperlipidemia, coronary atherosclerosis, puhi paka, a me ka momona.