Dalili na asali

1. Raunin jijiyoyin zuciya da jijiyoyin jini
Raunin ƙwayoyin jijiyoyin jini shine mafi mahimmanci kuma sanadin samuwar thrombus, kuma ya fi yawa a cikin cututtukan rheumatic da infective endocarditis, mummunan ulcers na atherosclerotic plaque, wuraren rauni na jijiyoyin jini ko kumburi, da sauransu. Akwai kuma hypoxia, shock, sepsis da ƙwayoyin cuta endotoxins waɗanda ke haifar da cututtuka iri-iri a cikin jiki.
Bayan raunin fata, sinadarin collagen da ke ƙarƙashin endothelium yana kunna tsarin coagulation, yana haifar da coagulation mai yaɗuwa a cikin jijiyoyin jini, kuma thrombus suna samuwa a cikin microcirculation na dukkan jiki.

2. Guduwar jini mara kyau
Yana nufin raguwar kwararar jini da kuma samar da eddies a cikin kwararar jini, da sauransu, kuma abubuwan da ke kunna coagulation da thrombin suna isa ga yawan da ake buƙata don coagulation a yankin, wanda ke taimakawa wajen samar da thrombus. Daga cikinsu, jijiyoyin jini sun fi saurin kamuwa da thrombus, wanda ya fi yawa a cikin marasa lafiya da ke fama da gazawar zuciya, rashin lafiya na yau da kullun da kuma hutawa bayan tiyata. Bugu da ƙari, kwararar jini a cikin zuciya da jijiyoyin jini yana da sauri, kuma ba shi da sauƙi a samar da thrombus. Duk da haka, lokacin da kwararar jini a cikin atrium na hagu, aneurysm, ko reshe na jijiyoyin jini yana da jinkiri kuma eddy current yana faruwa yayin stenosis na mitral bawul, yana kuma iya haifar da thrombosis.

3. Ƙara yawan zubar jini
Gabaɗaya, ƙwayoyin platelets da abubuwan da ke haifar da coagulation a cikin jini suna ƙaruwa, ko kuma aikin tsarin fibrinolytic yana raguwa, wanda ke haifar da yanayin coagulation a cikin jini, wanda ya fi yawa a cikin yanayin gado da kuma wanda aka samu ta hanyar coagulation mai yawa.

4. Yanayin gado mai yawan danshi
Yana da alaƙa da lahani na abubuwan da ke haifar da coagulation na gado, lahani na furotin C da furotin S, da sauransu. Daga cikinsu, maye gurbin kwayar halittar factor V da aka fi sani, ƙimar maye gurbin wannan kwayar halitta na iya kaiwa kashi 60% a cikin marasa lafiya da ke fama da thrombosis na jijiyoyin jini masu maimaitawa.

5. Yanayin da za a iya haɗa shi da yawan coagulable
Ana yawan ganinsa a cikin ciwon daji na pancreas, ciwon huhu, ciwon nono, ciwon daji na prostate, ciwon daji na ciki da sauran ciwace-ciwacen da suka ci gaba da yaduwa, wanda ke haifar da sakin abubuwan da ke haifar da coagulant ta hanyar ƙwayoyin cutar kansa; Hakanan yana iya faruwa a cikin mummunan rauni, ƙonewa mai yawa, babban tiyata ko bayan haihuwa idan akwai babban asarar jini, da kuma a cikin yanayi kamar hawan jini na ciki, hyperlipidemia, atherosclerosis na zuciya, shan taba, da kiba.