He mahi nui te toto toto me te toto toto i roto i te tinana tangata, e pā ana ki ngā oko toto, ngā pereti toto, ngā mea whakapūpū toto, ngā pūmua ārai toto, me ngā pūnaha fibrinolytic. He huinga pūnaha taurite ēnei e whakarite ana i te rere noa o te toto i roto i te tinana tangata. He rere tonu te rere, kāore e maringi i waho o te oko toto (totoka) kāore hoki e whakapūpū toto i roto i te oko toto (totoka).

Ko te tikanga o te thrombosis me te hemostasis e wehea ana kia toru ngā taahiraa:

Ko te nuinga o te wā, ko te pakitara o te oko toto, ko ngā pūtau endothelial, me ngā platelets te wāhi o te hemostasis tuatahi. I muri i te whara o te oko toto, ka tere te kohikohi o ngā platelets hei aukati i te toto.

Ko te hemostasis tuarua, e mōhiotia ana ko te hemostasis plasma, ka whakahohe i te pūnaha toto toto hei huri i te fibrinogen hei fibrin hononga-whiti kore e rewa, ka hanga he putunga nui.

Ko te fibrinolysis, e pakaru ana i te toto totoka fibrin ka whakahoki mai i te rere o te toto ki te tikanga noa.

He mea whakarite tika ia taahiraa kia mau tonu te taurite. Mā ngā hapa o tētahi hononga ka ara ake ngā mate e pā ana.

Ko ngā mate toto he kupu whānui mō ngā mate e puta mai ana i ngā tikanga toto rerekē. Ka taea te wehewehe i ngā mate toto ki ngā wāhanga e rua: te tuku iho me te whiwhi, ā, ko ngā whakaaturanga haumanu ko te toto i ngā wāhanga rerekē. Ko ngā mate toto whānau, ko te hemophilia A noa (te korenga o te tauwehe toto VIII), ko te hemophilia B (te korenga o te tauwehe toto IX) me ngā rerekētanga toto i puta mai i te korenga o te fibrinogen; ko ngā mate toto i puta mai, he mea noa. Kei reira ngā mate toto e whakawhirinaki ana ki te huaora K, ngā tauwehe toto rerekē i puta mai i te mate ate, me ētahi atu.

Ko ngā mate thromboembolic te nuinga o te wā ka wehea ki te thrombosis arterial me te thromboembolism venous (venousthromboembolism, VTE). He nui ake te kitea o te thrombosis arterial i roto i ngā uaua coronary, ngā uaua cerebral, ngā uaua mesenteric, me ngā uaua peka, me ētahi atu. He maha ngā wā ka ohorere te tīmatanga, ā, ka puta pea he mamae nui ā-rohe, pērā i te angina pectoris, te mamae puku, te mamae nui o ngā peka, me ētahi atu; ka puta mai i te ischemia kiko me te hypoxia i roto i ngā wāhanga e tika ana mō te tuku toto. He rerekē te hanganga me te mahi o te okana, te kiko, pērā i te myocardial infarction, te ngoikore o te ngakau, te cardiogenic shock, te arrhythmia, te raruraru o te hinengaro me te hemiplegia, me ētahi atu; ka puta te thrombus i te embolism cerebral, te renal embolism, te splenic embolism me ētahi atu tohu me ngā tohu e pā ana. Ko te thrombosis venous te momo thrombosis uaua hohonu tino noa i ngā pito o raro. He mea noa i roto i ngā uaua hohonu pērā i te uaua popliteal, te uaua femoral, te uaua mesenteric, me te uaua portal. Ko ngā whakaaturanga intuitive ko te pupuhi ā-rohe me te matotoru koretake o ngā pito o raro. Ko te thromboembolism e pā ana ki te wehenga o te thrombus mai i te wāhi i hangaia ai, ka ārai katoa, ka ārai rānei i ētahi o ngā oko toto i te wā e neke tahi ana me te rere o te toto, ka puta te ischemia, te hypoxia, te necrosis (te thrombosis arterial) me te pupū, te edema (te tukanga pathological o te thrombosis venous). I muri i te hinganga o te thrombosis uaua hohonu o te pito o raro, ka taea e ia te tomo ki te uaua pūkahukahu me te rere o te toto, ā, ka puta ngā tohu me ngā tohu o te embolism pūkahukahu. Nō reira, he mea tino nui te ārai i te thromboembolism venous.