I-D-dimer iwumkhiqizo wokuwohloka we-fibrin, ovame ukusetshenziswa ekuhlolweni kokusebenza kwe-coagulation.Izinga layo elijwayelekile lingu-0-0.5mg/L.Ukwanda kwe-D-dimer kungase kuhlotshaniswe nezici zomzimba ezifana nokukhulelwa, noma Kuhlobene nezici ze-pathological ezifana nezifo ze-thrombotic, izifo ezithathelwanayo, nezimila ezimbi.Kutuswa ukuthi iziguli ziye emnyangweni we-hematology esibhedlela ukuze zelashwe kusenesikhathi.

1. Izici ze-physiological:
Ngesikhathi sokukhulelwa, amazinga e-hormone emzimbeni azoshintsha, okungakhuthaza ukuwohloka kwe-fibrin ukukhiqiza i-D-dimer, engabangela ukwanda kwe-D-dimer egazini, kodwa ngokuvamile ingaphakathi kwebanga elivamile noma ikhuphuke kancane, okuyinto kuyinto evamile yokuphila komzimba futhi ngokuvamile ayidingi ukwelashwa okukhethekile.

2. Izici ze-Pathological:
1. I-Thrombotic disease: Uma kunesifo sokuqina kwemithambo emzimbeni, njenge-deep vein thrombosis, i-pulmonary embolism, njll., kungase kuholele ekusebenzeni okungavamile kwegazi, kwenze igazi libe sesimweni sokungaguquki, futhi kushukumise ukungasebenzi kahle kwesistimu ye-fibrinolytic, okuholela ku-D-dimerization Ukwanda kwemikhiqizo yokuwohloka kwe-fibrin njengomzimba nezinye i-fibrin, okuholela ekwandeni kwe-D-dimer egazini.Ngalesi sikhathi, ngaphansi kokuqondisa kukadokotela, i-recombinant streptokinase yomjovo, i-urokinase yomjovo nezinye izidakamizwa ingasetshenziswa ekwelapheni ukuvimbela ukwakheka kwe-thrombus;

2. Izifo ezithathelwanayo: Uma kukhona isifo esibi emzimbeni, njenge-sepsis, ama-microorganisms e-pathogenic egazini akhula ngokushesha emzimbeni, ahlasele izicubu nezitho zomzimba wonke, abulale isimiso se-microvascular, futhi akhe i-capillary thrombosis. emzimbeni wonke.Kuzoholela ekusabalaliseni kwe-intravascular coagulation kuwo wonke umzimba, kukhuthaze ukuthuthukiswa komsebenzi we-fibrinolytic emzimbeni, futhi kubangele ukwanda kwe-D-dimer egazini.Ngalesi sikhathi, isiguli singasebenzisa imishanguzo elwa namagciwane njenge-cefoperazone sodium ne-sulbactam sodium ukuze umjove njengoba eyalelwe udokotela.;

3. Izimila eziyingozi: Amangqamuzana e-tumor ayingozi azokhulula i-procoagulant, akhuthaze ukwakheka kwe-thrombus emithanjeni yegazi, bese evula uhlelo lwe-fibrinolytic, okuholela ekwandeni kwe-D-dimer egazini.Ngalesi sikhathi, umjovo we-paclitaxel, I-Chemotherapy ngemijovo yezidakamizwa ezinjenge-cisplatin.Ngesikhathi esifanayo, ungakwazi futhi ukwenza ukuhlinzwa ukuze ususe isimila ngokusho kweseluleko sikadokotela, okulungele ukubuyiswa kwesifo.