Ikhithi yexesha le-Thrombin (TT)

I-TT ibhekisela kwixesha lokuvala igazi emva kokongeza i-thrombin esemgangathweni kwi-plasma.Kwindlela ye-coagulation eqhelekileyo, i-thrombin eyenziwayo iguqula i-fibrinogen ibe yi-fibrin, enokubonakaliswa yi-TT.Ngenxa yokuba i-fibrin (iproto) iimveliso zokunciphisa (i-FDP) inokwandisa i-TT, abanye abantu basebenzisa i-TT njengovavanyo lokuhlola inkqubo ye-fibrinolytic.

Ukubaluleka kweklinikhi:

(1) I-TT ithatha ixesha elide (ngaphezu kwe-3s ngaphezu kolawulo oluqhelekileyo) i-heparin kunye ne-heparinoid izinto zanda, ezifana ne-lupus erythematosus, isifo sesibindi, isifo sezintso, njl njl. I-Fibrinogenemia ephantsi (ayikho), i-fibrinogenemia engaqhelekanga.

(2) I-FDP yanda: njenge-DIC, i-fibrinolysis ephambili kunye nokunye.

Ixesha elide le-thrombin (TT) libonakala ekunciphiseni kwe-plasma fibrinogen okanye ukungahambi kakuhle kwesakhiwo;ukusetyenziswa kwekliniki ye-heparin, okanye ukunyuka kwe-heparin-like anticoagulants kwisifo sesibindi, isifo sezintso kunye ne-systemic lupus erythematosus;ukungasebenzi kakuhle kwenkqubo ye-fibrinolytic.Ixesha elifutshane le-thrombin libonakala phambi kwe-calcium ions egazini, okanye igazi li-acidic, njl.

Ixesha le-Thrombin (TT) libonisa i-anticoagulant substance emzimbeni, ngoko ukwandiswa kwayo kubonisa i-hyperfibrinolysis.Umlinganiselo lixesha lokubunjwa kwe-fibrin emva kokongeza i-thrombin esemgangathweni, ngoko kwi-low (akukho) isifo se-fibrinogen, i-DIC kunye ne-Lode phambi kwezinto ze-heparinoid (ezifana ne-heparin therapy, i-SLE kunye nesifo sesibindi, njl.).Ukunciphisa i-TT akunakubaluleka kweklinikhi.

Uluhlu oluQhelekileyo:

Ixabiso eliqhelekileyo yi-16~18s.Ukugqithisa ulawulo oluqhelekileyo ngaphezu kwe-3s ayiqhelekanga.

Phawula:

(1) I-Plasma ayifanele ibe ngaphezu kwe-3h kwiqondo lokushisa.

(2) I-disodium edetate kunye ne-heparin akufanele isetyenziswe njenge-anticoagulants.

(3) Ekupheleni kovavanyo, indlela yetyhubhu yokuvavanya isekelwe kwi-coagulation yokuqala xa i-turbidity ibonakala;indlela yesitya seglasi isekelwe kwisakhono sokucaphukisa i-fibrin filaments

Izifo ezinxulumeneyo:

Lupus erythematosus