Ikhithi yeXesha leThromboplastin esebenzayo (APTT)

Umlinganiselo we-APTT lolona vavanyo luxhaphakileyo lovavanyo lokuhlola olunovakalelo lweklinikhi ukubonisa umsebenzi wokudityaniswa kwenkqubo ye-endogenous coagulation.Isetyenziselwa ukufumanisa iziphene ze-endogenous coagulation factor kunye ne-inhibitors ezinxulumeneyo kunye nokuhlola isenzeko sokuxhathisa iprotheyini C.Inoluhlu olubanzi lwezicelo malunga nokuhlolwa, ukubeka iliso kwonyango lwe-heparin, ukuxilongwa kwangaphambili kwe-dissemination intravascular coagulation (DIC), kunye noviwo lwangaphambili.

Ukubaluleka kweklinikhi:

I-APTT yi-coagulation function test index ebonisa indlela ye-coagulation engapheliyo, ngokukodwa umsebenzi obanzi wezinto zokudibanisa kwinqanaba lokuqala.Isetyenziselwa ngokubanzi ukukhangela kunye nokumisela iziphene ze-coagulation izinto kwindlela engapheliyo, njenge-factor Ⅺ, Ⅷ, Ⅸ, ingasetyenziselwa ukuxilongwa kwangaphambili kwezifo ezophayo kunye nokubeka iliso kwilabhoratri ye-heparin anticoagulation therapy.

1. Ixesha elide: linokubonwa kwi-hemophilia A, i-hemophilia B, isifo sesibindi, i-intestinal sterilization syndrome, i-anticoagulants yomlomo, i-diffuse intravascular coagulation, i-hemophilia epholileyo;FXI, FXII intsilelo;igazi Izinto ze-Anticoagulant (i-coagulation factor inhibitors, i-lupus anticoagulants, i-warfarin okanye i-heparin) yanda;kwatofelwa izixa ezikhulu zegazi eligciniweyo.

2. Ukunciphisa: Ingabonwa kwimeko ye-hypercoagulable, izifo ze-thromboembolic, njl.

Uluhlu lwereferensi yexabiso eliqhelekileyo

Ixabiso eliqhelekileyo lereferensi yexesha elisebenzayo le-thromboplastin (APTT): 27-45 imizuzwana.

Ukulumkela

1. Kuphephe ukulinganisa i-hemolysis.I-hemolyzed specimen iqukethe i-phospholipids ekhutshwe ngokuphuka kwe-membrane yeseli ebomvu ekhulile, eyenza i-APTT ibe ngaphantsi kwexabiso elilinganisiweyo le-non-hemolyzed specimen.

2. Izigulane akufanele zibandakanyeke kwimisebenzi enzima kwimizuzu engama-30 ngaphambi kokufumana isampuli yegazi.

3. Emva kokuqokelela isampulu yegazi, vuthulula ngobunono ityhubhu yokuvavanya equkethe isampuli yegazi 3 ukuya kumaxesha e-5 ukuze udibanise ngokupheleleyo isampuli yegazi kunye ne-anticoagulant kwi-tube yokuvavanya.

4. Iisampuli zegazi kufuneka zithunyelwe ukuze zihlolwe ngokukhawuleza.