Ngwa ngwa Thrombin (TT)

TT na-ezo aka n'oge mgbụsị akwụkwọ ọbara mgbe agbakwunyere thrombin ọkọlọtọ na plasma.N'okporo ụzọ coagulation nkịtị, thrombin emepụtara na-agbanwe fibrinogen n'ime fibrin, nke nwere ike igosipụta site na TT.N'ihi na fibrin (proto) ngwaahịa mmebi (FDP) nwere ike ịgbatị TT, ụfọdụ ndị na-eji TT dị ka nyocha nyocha maka usoro fibrinolytic.

Mkpa ụlọ ọgwụ:

(1) TT na-agbatị ogologo oge (karịa 3s karịa njikwa nkịtị) heparin na heparinoid bekee na-abawanye, dị ka lupus erythematosus, ọrịa imeju, ọrịa akụrụ, wdg. Ala (enweghị) fibrinogenemia, fibrinogenemia na-adịghị mma.

(2) FDP mụbara: dị ka DIC, isi fibrinolysis na ndị ọzọ.

A na-ahụ ogologo oge thrombin (TT) na mbelata nke fibrinogen plasma ma ọ bụ ihe arụrụ arụ;ngwa ụlọ ọgwụ nke heparin, ma ọ bụ ịba ụba heparin dị ka anticoagulants na ọrịa imeju, ọrịa akụrụ na sistem lupus erythematosus;hyperfunction nke sistem fibrinolytic.A na-ahụ oge thrombin dị mkpụmkpụ na ọnụnọ calcium ion n'ime ọbara, ma ọ bụ ọbara bụ acidic, wdg.

Oge thrombin (TT) bụ ngosipụta nke ihe na-egbochi arịa ọbara n'ime ahụ, yabụ ndọtị ya na-egosi hyperfibrinolysis.Ntụle bụ oge e guzobere fibrin mgbe agbakwunyere thrombin ọkọlọtọ, ya mere na obere (ọ dịghị) ọrịa fibrinogen, DIC na ogologo oge na ọnụnọ nke heparinoids (dịka ọgwụgwọ heparin, SLE na ọrịa imeju, wdg).Mbelata nke TT enweghị ihe ọ pụtara ụlọ ọgwụ.

Oke Okirikiri:

Uru nkịtị bụ 16 ~ 18s.Ịgafe njikwa nkịtị maka ihe karịrị 3s bụ ihe na-adịghị mma.

Mara:

(1) Plasma ekwesịghị ịgafe awa 3 n'ime ụlọ okpomọkụ.

(2) Disodium edetate na heparin ekwesịghị iji dị ka ọgwụ mgbochi.

(3) Na njedebe nke nnwale ahụ, usoro tube ule na-adabere na coagulation mbụ mgbe turbidity pụtara;usoro efere iko na-adabere n'ikike ịkpali fibrin filaments

Ọrịa ndị emetụtara:

Lupus erythematosus