Ikhithi Yesikhathi ye-Thrombin (TT)

I-TT ibhekisela esikhathini sokujiyisa kwegazi ngemva kokwengeza i-thrombin evamile ku-plasma.Endleleni evamile yokuhlangana, i-thrombin ekhiqiziwe iguqula i-fibrinogen ibe yi-fibrin, engaboniswa yi-TT.Ngenxa yokuthi imikhiqizo ye-fibrin (proto) degradation (FDP) inganweba i-TT, abanye abantu basebenzisa i-TT njengokuhlola ukuhlolwa kwesistimu ye-fibrinolytic.

Ukubaluleka komtholampilo:

(1) I-TT ihlala isikhathi eside (ngaphezu kwe-3s ngaphezu kokulawula okujwayelekile) i-heparin kanye nezinto ze-heparinoid zanda, njenge-lupus erythematosus, isifo sesibindi, isifo sezinso, njll. I-Fibrinogenemia ephansi (ayikho), i-fibrinogenemia engavamile.

(2) I-FDP yanda: njenge-DIC, i-fibrinolysis eyinhloko njalonjalo.

Isikhathi eside se-thrombin (TT) sibonakala ekunciphiseni kwe-plasma fibrinogen noma ukungahambi kahle kwesakhiwo;ukusetshenziswa komtholampilo kwe-heparin, noma ukwanda kwama-anticoagulants afana ne-heparin esifweni sesibindi, isifo sezinso kanye ne-systemic lupus erythematosus;ukungasebenzi kahle kwesistimu ye-fibrinolytic.Isikhathi esifushane se-thrombin sibonakala lapho kukhona i-calcium ions egazini, noma igazi line-acidic, njll.

Isikhathi se-Thrombin (TT) siwukubonakaliswa kwento ye-anticoagulant emzimbeni, ngakho ukunwetshwa kwayo kukhombisa i-hyperfibrinolysis.Ukulinganisa yisikhathi sokubunjwa kwe-fibrin ngemuva kokwengeza i-thrombin ejwayelekile, ngakho-ke ku-low (akukho) isifo se-fibrinogen, i-DIC kanye Nesikhathi eside ebukhoneni bezinto ze-heparinoid (njengokwelashwa kwe-heparin, i-SLE nesifo sesibindi, njll.).Ukufinyezwa kwe-TT akunakubaluleka komtholampilo.

Ibanga elijwayelekile:

Inani elivamile lingu-16~18s.Ukweqa ukulawula okuvamile okungaphezu kwama-3s akuvamile.

Qaphela:

(1) I-Plasma akufanele idlule u-3h ezingeni lokushisa elivamile.

(2) I-disodium edetate ne-heparin akufanele isetshenziswe njengama-anticoagulants.

(3) Ekupheleni kokuhlolwa, indlela ye-tube yokuhlola isekelwe ku-coagulation yokuqala lapho kuvela i-turbidity;indlela yesitsha sengilazi isekelwe ekhonweni lokucasula i-fibrin filaments

Izifo ezihlobene:

I-Lupus erythematosus