Ikhithi yeXesha leThrombin (TT)

I-TT ibhekisa kwixesha lokujiya kwegazi emva kokongeza i-thrombin eqhelekileyo kwi-plasma. Kwindlela eqhelekileyo yokujiya, i-thrombin evelisiweyo iguqula i-fibrinogen ibe yi-fibrin, enokubonakaliswa yi-TT. Ngenxa yokuba iimveliso zokujiya kwe-fibrin (proto) (FDP) zinokwandisa i-TT, abanye abantu basebenzisa i-TT njengovavanyo lokuhlola inkqubo ye-fibrinolytic.

Ukubaluleka kweklinikhi:

(1) I-TT ithatha ixesha elide (ngaphezulu kwemizuzwana emi-3 kunolawulo oluqhelekileyo) izinto ze-heparin kunye ne-heparinoid ziyanda, ezifana ne-lupus erythematosus, isifo sesibindi, isifo sezintso, njl. I-fibrinogenemia ephantsi (ayikho) , i-fibrinogenemia engaqhelekanga.

(2) I-FDP inyukile: njenge-DIC, i-primary fibrinolysis njalo njalo.

Ixesha elide le-thrombin (TT) libonakala ekunciphiseni kwe-plasma fibrinogen okanye ukungaqheleki kwesakhiwo; ukusetyenziswa kwe-heparin kwiklinikhi, okanye ukwanda kwe-heparin-like anticoagulants kwisifo sesibindi, isifo sezintso kunye ne-systemic lupus erythematosus; ukusebenza ngokugqithisileyo kwenkqubo ye-fibrinolytic. Ixesha elifutshane le-thrombin libonakala xa kukho i-calcium ions egazini, okanye igazi line-asidi, njl.

Ixesha le-Thrombin (TT) libonisa into elwa ne-anticoagulant emzimbeni, ngoko ke ukwandiswa kwayo kubonisa i-hyperfibrinolysis. Umlinganiselo lixesha lokwakheka kwe-fibrin emva kokongeza i-thrombin eqhelekileyo, ngoko ke kwisifo se-fibrinogen esiphantsi (esingenazo), i-DIC kunye ne-Dilonged xa kukho izinto ze-heparinoid (ezifana nonyango lwe-heparin, i-SLE kunye nesifo sesibindi, njl.njl.). Ukufinyezwa kwe-TT akunamsebenzi weklinikhi.

Uluhlu oluQhelekileyo:

Ixabiso eliqhelekileyo yi-16 ~ 18s. Ukudlula ulawulo oluqhelekileyo ngaphezu kwe-3s akuvamile.

Phawula:

(1) I-Plasma akufuneki idlule iiyure ezi-3 kubushushu begumbi.

(2) I-Disodium edetate kunye ne-heparin akufanele zisetyenziswe njengezinto ezithintela ukugabha kwegazi.

(3) Ekupheleni kovavanyo, indlela yetyhubhu yovavanyo isekelwe ekujiyeni kokuqala xa kuvela i-turbidity; indlela yesitya seglasi isekelwe kubuchule bokuvusa iifilaments ze-fibrin

Izifo ezinxulumene noko:

I-Lupus erythematosus