Thrombosis le hemostasis ke mesebetsi ea bohlokoa ea 'mele oa motho, e kenyeletsang methapo ea mali, li-platelet, lintho tse kopanyang mali, liprotheine tse thibelang ho ruruha ha mali, le litsamaiso tsa fibrinolytic. Ke sete ea litsamaiso tse leka-lekaneng hantle tse netefatsang phallo e tloaelehileng ea mali 'meleng oa motho. Ho potoloha ho tsoelang pele ha phallo, ha ho tšolohe mothapong oa mali (ho tsoa mali) kapa ho hoama mothapong oa mali (thrombosis).

Mokhoa oa thrombosis le hemostasis hangata o arotsoe ka mekhahlelo e meraro:

Ho hemostasis ha pele ho ameha haholo leboteng la mothapo, lisele tsa endothelial le li-platelet. Kamora kotsi ea mothapo, li-platelet lia bokana kapele ho emisa ho tsoa mali.

Hemostasis ea bobeli, e tsejoang hape e le plasma hemostasis, e kenya tšebetsong sistimi ea ho kopanya mali ho fetola fibrinogen hore e be fibrin e kopantsoeng ka tsela e sa qhibiliheng, e etsang maqeba a maholo.

Fibrinolysis, e roba fibrin clot le ho tsosolosa phallo ea mali e tloaelehileng.

Mohato o mong le o mong o laolwa ka nepo ho boloka boemo ba tekano. Liphoso tse hokahaneng efe kapa efe li tla lebisa mafung a amanang le tsona.

Mathata a ho tsoa mali ke lentsoe le akaretsang bakeng sa mafu a bakoang ke mekhoa e sa tloaelehang ea hemostasis. Mathata a ho tsoa mali a ka aroloa ka mekhahlelo e 'meli: lefutso le fumanoeng, 'me lipontšo tsa kliniki li bakoa haholo-holo ke ho tsoa mali likarolong tse fapaneng. Mathata a ho tsoa mali a tsoaloang ke 'mele, hemophilia e tloaelehileng A (khaello ea coagulation factor VIII), hemophilia B (khaello ea coagulation factor IX) le mathata a ho ruruha a bakoang ke khaello ea fibrinogen; mathata a ho tsoa mali a fumanoeng, a tloaelehileng Ho na le khaello ea coagulation factor e itšetlehileng ka vithamine K, mabaka a sa tloaelehang a coagulation a bakoang ke lefu la sebete, jj.

Mafu a Thromboembolic a arotsoe haholo ka thrombosis ea methapo le venous thromboembolism (venousthromboembolism, VTE). Thrombosis ea methapo e atile haholo methapong ea pelo, methapong ea boko, methapong ea mesenteric, le methapong ea maoto, jj. Ho qala hangata ho etsahala ka tšohanyetso, 'me bohloko bo boholo ba sebaka bo ka hlaha, joalo ka angina pectoris, bohloko ba mpa, bohloko bo boholo maotong, jj.; e bakoa ke ischemia ea lisele le hypoxia likarolong tse amehang tsa phepelo ea mali Setho se sa tloaelehang, sebopeho sa lisele le ts'ebetso, joalo ka infarction ea myocardial, ho hloleha ha pelo, ho tšoha ha pelo, arrhythmia, ho ferekana ha kelello le hemiplegia, jj.; ho tšoloha ha thrombus ho baka cerebral embolism, liphio embolism, splenic embolism le matšoao le matšoao a mang a amanang le ona. Thrombosis ea methapo ke mofuta o tloaelehileng haholo oa thrombosis ea methapo e tebileng maotong a ka tlase. E tloaelehile methapong e tebileng joalo ka mothapo oa popliteal, mothapo oa femoral, mothapo oa mesenteric, le mothapo oa portal. Lipontšo tse utloahalang ke ho ruruha ha sebaka le botenya bo sa tsitsang ba maoto a ka tlase. Thromboembolism e bolela ho arohana ha thrombus sebakeng sa ho thehoa, ho thibela methapo e meng ea mali ka karolo e itseng kapa ka ho feletseng nakong ea ts'ebetso ea ho tsamaea le phallo ea mali, e leng se bakang ischemia, hypoxia, necrosis (thrombosis ea methapo) le ho thibana, ho ruruha (ts'ebetso ea pathological ea venous thrombosis). Kamora hore thrombosis ea methapo e tebileng ea karolo e ka tlase e oe, e ka kena mothapong oa matšoafo ka phallo ea mali, 'me matšoao le matšoao a embolism ea matšoafo a hlaha. Ka hona, thibelo ea thromboembolism ea methapo e bohlokoa haholo.