Kuyerera kweropa mumuviri neropa muropa (hemostasis) mabasa akakosha emuviri wemunhu, anosanganisira mitsipa yeropa, maplatelet, zvinhu zvinobatanidza ropa, mapuroteni anorwisa ropa muropa, uye masisitimu efibrinolytic. Izvi zvikamu zvemasisitimu akanyatsorongeka anovimbisa kuyerera kweropa mumuviri wemunhu. Kutenderera kweropa nguva dzose, pasina kubuda ropa mutsinga yeropa (hemorrhage) kana kuonda mutsinga yeropa (thrombosis).

Maitiro e thrombosis uye hemostasis anowanzo kupatsanurwa kuita matanho matatu:

Kupera kweropa kwekutanga kunonyanya kuitika mumadziro etsinga, masero e endothelial, uye maplatelet. Mushure mekukuvadzwa kwetsinga, maplatelet anoungana nekukurumidza kuti amise kubuda ropa.

Kupera kweropa kwechipiri, kunozivikanwawo se plasma hemostasis, kunoita kuti system yekubatanidza ropa ishande kuti ishandure fibrinogen kuita insoluble cross-linked fibrin, iyo inoumba mavanga makuru.

Fibrinolysis, iyo inoputsa fibrin clot uye inodzorera kufamba kweropa kwakajairika.

Danho rega rega rinodzorwa nemazvo kuti pave nekuenzana. Zvikanganiso zviri muchikamu chipi nechipi zvinozokonzera zvirwere zvine chekuita nazvo.

Matambudziko ekubuda ropa izwi rinowanzo shandiswa kureva zvirwere zvinokonzerwa nemaitiro asina kujairika ekubuda ropa. Matambudziko ekubuda ropa anogona kukamurwa kuita mapoka maviri: enhaka neanowanikwa, uye zviratidzo zvekiriniki zvinonyanya kubuda ropa muzvikamu zvakasiyana. Matambudziko ekubuda ropa anokonzerwa nekubereka, common hemophilia A (kushomeka kwe coagulation factor VIII), hemophilia B (kushomeka kwe coagulation factor IX) uye kusagadzikana kwe coagulation kunokonzerwa ne fibrinogen kushomeka; acquired bleeding disorders, common Kune kushomeka kwe coagulation factor deficiency vitamin K, abnormal coagulation factors kunokonzerwa nechirwere chechiropa, nezvimwewo.

Zvirwere zveThromboembolic zvinonyanya kukamurwa muzvikamu zviviri: arterial thrombosis uye venous thromboembolism (venousthromboembolism, VTE). Arterial thrombosis inowanzoonekwa mu coronary arteries, cerebral arteries, mesenteric arteries, uye limb arteries, nezvimwewo. Kutanga kwacho kunowanzo itika kamwe kamwe, uye kurwadziwa kwakanyanya kunogona kuitika, senge angina pectoris, kurwadziwa mudumbu, kurwadziwa kwakanyanya mumakumbo, nezvimwewo; zvinokonzerwa ne ischemia yenyama uye hypoxia muzvikamu zveropa zvine chekuita neropa. Nhengo dzisina kujairika, chimiro chenyama uye mashandiro ayo, senge myocardial infarction, heart failure, cardiogenic shock, arrhythmia, kusagadzikana kwekuziva uye hemiplegia, nezvimwewo; thrombus shedding inokonzera cerebral embolism, renal embolism, splenic embolism nezvimwe zviratidzo zvine chekuita nazvo. Venous thrombosis ndiyo inonyanya kuwanikwa ye deep vein thrombosis mumakumbo ekupedzisira. Inowanzoitika mumitsipa yakadzika senge popliteal vein, femoral vein, mesenteric vein, uye portal vein. Zviratidzo zvepfungwa ndezvekuzvimba kwenzvimbo uye ukobvu husingaenderane hwemakumbo epasi. Kuputika kweropa (thromboembolism) zvinoreva kubviswa kweropa kubva panzvimbo yakaumbwa, kuvharira mitsipa yeropa zvishoma kana zvachose panguva yekufamba kweropa, zvichikonzera ischemia, hypoxia, necrosis (arterial thrombosis) uye kuzara kweropa, kuzvimba (pathological process ye venous thrombosis). Mushure mekunge thrombosis yeropa yakadzika yemucheto wepasi yadonha, inogona kupinda mutsinga yeropa nekufamba kweropa, uye zviratidzo zve pulmonary embolism zvinoonekwa. Nokudaro, kudzivirira thromboembolism yeropa kwakanyanya kukosha.