Thrombosis na hemostasis bụ ọrụ dị mkpa nke ahụ mmadụ, gụnyere arịa ọbara, platelets, ihe ndị na-akpata coagulation, protein anticoagulant, na sistemu fibrinolytic. Ha bụ usoro nke sistemu ndị a kapịrị ọnụ nke na-ahụ na ọbara na-erugharị n'ahụ mmadụ. Mgbasa na-aga n'ihu, ọ bụghị nke na-apụta n'ime arịa ọbara (ọbara ọgbụgba) ma ọ bụ nke na-agbakọta n'ime arịa ọbara (thrombosis).

A na-ekewakarị usoro nke thrombosis na hemostasis n'ime usoro atọ:

Mbido ọbara ọgbụgba na-abụkarị ihe na-emetụta mgbidi arịa ọbara, mkpụrụ ndụ endothelial, na platelets. Mgbe mmerụ ahụ arịa ọbara gasịrị, platelets na-agbakọta ngwa ngwa iji kwụsị ọbara ọgbụgba.

Hemostasis nke abụọ, nke a makwaara dị ka plasma hemostasis, na-eme ka usoro coagulation gbanwee fibrinogen ka ọ bụrụ fibrin na-anaghị agbaze agbaze, nke na-emepụta nnukwu mkpụkọ ọbara.

Fibrinolysis, nke na-agbaji eriri fibrin ma na-eweghachi usoro ọbara nkịtị.

A na-ahazi usoro ọ bụla nke ọma iji nọgide na-enwe nguzozi. Nrụhie dị na njikọ ọ bụla ga-ebute ọrịa ndị yiri ya.

Nsogbu ọbara ọgbụgba bụ okwu a na-ejikarị eme ihe maka ọrịa ndị usoro hemostasis na-adịghị mma na-akpata. Enwere ike kewaa nsogbu ọbara ọgbụgba n'ụzọ dị iche iche: nke sitere na ihe nketa na nke enwetara, ihe mgbaàmà ahụike bụkarị ọbara ọgbụgba n'akụkụ dị iche iche. Nsogbu ọbara ọgbụgba sitere na ọmụmụ nwa, hemophilia A (enweghị coagulation factor VIII), hemophilia B (enweghị coagulation factor IX) na nsogbu coagulation nke sitere na enweghị fibrinogen; nsogbu ọbara ọgbụgba enwetara, nke a na-ahụkarị E nwere ụkọ coagulation nke dabere na vitamin K, ihe ndị na-adịghị mma nke ọrịa imeju kpatara, wdg.

Ọrịa thromboembolic na-ekewakarị n'ime akwara akwara na akwara akwara (venousthromboembolism, VTE). Ọkpụkpụ akwara na-adịkarị na akwara akwara obi, akwara ụbụrụ, akwara mesenteric, na akwara ụkwụ, wdg. Mmalite ya na-abụkarị mberede, ihe mgbu dị ukwuu nwere ike ime, dịka angina pectoris, mgbu afọ, nnukwu ihe mgbu na aka na ụkwụ, wdg.; ọ na-akpata ya site na ischemia anụ ahụ na hypoxia na akụkụ ọbara dị mkpa. Akụkụ ahụ na-adịghị mma, nhazi anụ ahụ na ọrụ ya, dị ka myocardial infarction, nkụda obi, cardiogenic shock, arrhythmia, nsogbu nke nsụhọ na hemiplegia, wdg.; mwepụ nke thrombus na-akpata embolism ụbụrụ, renal embolism, splenic embolism na ihe mgbaàmà na ihe mgbaàmà ndị ọzọ metụtara ya. Ọkpụkpụ akwara bụ ụdị thrombosis miri emi kachasị na nsọtụ ala. Ọ na-adịkarị na akwara miri emi dị ka popliteal vein, femoral vein, mesenteric vein, na portal vein. Ihe ngosi ndị a na-ahụ anya bụ ọzịza mpaghara na ọkpụrụkpụ na-adịghị agbanwe agbanwe nke nsọtụ ala. Thromboembolism pụtara iwepụ thrombus site na ebe e guzobere ya, igbochi ụfọdụ arịa ọbara n'ụzọ ụfọdụ ma ọ bụ kpamkpam n'oge usoro mmegharị na ọbara, na-akpata ischemia, hypoxia, necrosis (thrombosis arterial) na mkpọchi, edema (usoro ọrịa nke venous thrombosis). Mgbe thrombosis akwara miri emi nke nsọtụ ala daa, ọ nwere ike ịbanye na akwara akpa ume na mgbasa ọbara, ihe mgbaàmà na ihe ịrịba ama nke pulmonary embolism na-apụta. Ya mere, mgbochi nke venous thromboembolism dị oke mkpa.