Ikhithi Yesikhathi Se-Thrombin (TT)

I-TT ibhekisela esikhathini sokujiya kwegazi ngemva kokufaka i-thrombin ejwayelekile ku-plasma. Endleleni evamile yokujiya, i-thrombin ekhiqizwayo iguqula i-fibrinogen ibe yi-fibrin, engabonakaliswa yi-TT. Ngenxa yokuthi imikhiqizo yokujiya kwe-fibrin (proto) (FDP) ingandisa i-TT, abanye abantu basebenzisa i-TT njengesivivinyo sokuhlola uhlelo lwe-fibrinolytic.

Ukubaluleka komtholampilo:

(1) I-TT iyanda (ngaphezu kwamasekhondi angu-3 kunokulawula okuvamile) izinto ze-heparin ne-heparinoid ziyanda, njenge-lupus erythematosus, isifo sesibindi, isifo sezinso, njll. I-fibrinogenemia ephansi (ayikho) kanye ne-fibrinogenemia engavamile.

(2) I-FDP yanda: njenge-DIC, i-fibrinolysis eyinhloko njalo njalo.

Isikhathi eside se-thrombin (TT) sibonakala ekwehleni kwe-plasma fibrinogen noma ukukhubazeka kwesakhiwo; ukusetshenziswa kwe-heparin emtholampilo, noma ukwanda kwama-anticoagulants afana ne-heparin ezifweni zesibindi, izifo zezinso kanye ne-systemic lupus erythematosus; ukusebenza ngokweqile kohlelo lwe-fibrinolytic. Isikhathi esifushane se-thrombin sibonakala lapho kukhona ama-calcium ions egazini, noma igazi line-acidic, njll.

Isikhathi se-Thrombin (TT) siwukubonakaliswa kwento elwa nokuqina kwegazi emzimbeni, ngakho-ke ukwanda kwayo kubonisa i-hyperfibrinolysis. Ukulinganiswa yisikhathi sokwakheka kwe-fibrin ngemuva kokufaka i-thrombin ejwayelekile, ngakho-ke esifweni se-fibrinogen esiphansi (esingenayo), i-DIC kanye ne-Drange lapho kukhona izinto ze-heparinoid (njengokwelashwa kwe-heparin, i-SLE nesifo sesibindi, njll.). Ukufinyezwa kwe-TT akunakubaluleka kwezokwelapha.

Ibanga Elijwayelekile:

Inani elijwayelekile liyimizuzwana engu-16 ~ 18. Ukudlula ukulawula okujwayelekile isikhathi esingaphezu kwemizuzwana engu-3 akuvamile.

Qaphela:

(1) I-Plasma akufanele idlule amahora ama-3 ekushiseni kwegumbi.

(2) I-Disodium edetate kanye ne-heparin akufanele kusetshenziswe njengemithi yokunciphisa ukugabha kwegazi.

(3) Ekupheleni kokuhlolwa, indlela yethubhu yokuhlola isekelwe ekujiyeni kokuqala lapho kuvela ukungcola; indlela yesitsha sengilazi isekelwe emandleni okuvusa imicu ye-fibrin

Izifo ezihlobene:

I-Lupus erythematosus