TT inoreva nguva yekugwamba kweropa mushure mekuwedzera thrombin yakajairwa muplasma. Munzira yekugwamba kweropa, thrombin inogadzirwa inoshandura fibrinogen kuita fibrin, iyo inogona kuratidzwa neTT. Nekuti fibrin (proto) degradation products (FDP) inogona kuwedzera TT, vamwe vanhu vanoshandisa TT senzira yekuongorora fibrinolytic system.
Kukosha kwekiriniki:
(1) TT inowedzerwa nguva (inopfuura 3s kupfuura zvakajairwa) heparin uye heparinoid zvinhu zvinowedzera, zvakaita se lupus erythematosus, chirwere chechiropa, chirwere cheitsvo, nezvimwewo. Fibrinogenemia yakaderera (isina) uye fibrinogenemia isina kujairika.
(2) FDP yakawedzera: zvakaita seDIC, primary fibrinolysis nezvimwewo.
Nguva refu ye thrombin (TT) inoonekwa mukudzikira kwe plasma fibrinogen kana kusarongeka kwechimiro; kushandiswa kwe heparin mukiriniki, kana kuwedzera kwe heparin-like anticoagulants muzvirwere zvechiropa, chirwere cheitsvo uye systemic lupus erythematosus; kushanda zvakanyanya kwe fibrinolytic system. Nguva pfupi ye thrombin inoonekwa mukuvapo kwe calcium ions muropa, kana ropa rine acidic, nezvimwewo.
Nguva yeThrombin (TT) chiratidzo chechinhu chinodzivirira ropa mumuviri, saka kuwedzera kwayo kunoratidza hyperfibrinolysis. Kuyerwa inguva yekuumbwa kwefibrin mushure mekuwedzera standardized thrombin, saka muchirwere chefibrinogen chakaderera (chisina), DIC uye Nguva refu kana paine heparinoids (senge heparin therapy, SLE uye chiropa, nezvimwewo). Kupfupika kweTT hakuna kukosha mukiriniki.
Nzvimbo Yakajairika:
Kukosha kwakajairika imasekondi 16 ~ 18. Kupfuura kudzora kwakajairika kwemasekondi anopfuura matatu hakuna kujairika.
Cherechedza:
(1) Plasma haifanirwe kudarika maawa matatu patembiricha yemumba.
(2) Disodium edetate neheparin hazvifanirwe kushandiswa semishonga inorwisa kuungana kweropa.
(3) Pakupera kwekuyedza, nzira yechubhu yekuyedza inobva pakugwamba kwekutanga kana turbidity yaonekwa; nzira yedhishi regirazi inobva pakukwanisa kukonzera fibrin filaments
Zvirwere zvine chekuita nazvo:
Lupus erythematosus
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