Abacwaningi eMonash University baklame i-antibody entsha engavimbela iphrotheni ethile egazini ukuvimbela i-thrombosis ngaphandle kwemiphumela emibi engaba khona. Le antibody ingavimbela i-thrombosis ye-pathological, engabangela ukuhlaselwa yinhliziyo kanye nohlangothi ngaphandle kokuphazamisa ukusebenza okuvamile kokujiya kwegazi.

Ukuhlaselwa yinhliziyo kanye nohlangothi kusalokhu kuyizimbangela eziphambili zokufa kanye nokugula emhlabeni jikelele. Izindlela zokwelapha zamanje zokulwa nokuvuvukala kwegazi (i-anticoagulant) zingadala futhi ziyabangela izinkinga ezinkulu zokopha ngoba ziphazamisa nokujiya kwegazi okuvamile. Iziguli ezine kwezinhlanu ezithola ukwelashwa kwe-antiplatelet zisalokhu zinezehlakalo zenhliziyo eziphindaphindayo.

Ngakho-ke, imithi ekhona yokulwa nama-platelet ayikwazi ukusetshenziswa ngemithamo emikhulu. Ngakho-ke, ukusebenza kahle kwezokwelapha kusadumaza, futhi ukwelashwa kwesikhathi esizayo kudinga ukuhlelwa kabusha ngokuyisisekelo.

Indlela yocwaningo iwukuqala ngokunquma umehluko webhayoloji phakathi kokujiya okuvamile kanye nokujiya kwe-pathological, bese uthola ukuthi i-von Willebrand factor (VWF) ishintsha izakhiwo zayo lapho kwakheka i-thrombus eyingozi. Ucwaningo lwaklama i-antibody ethola futhi ivimbele kuphela lolu hlobo lwe-VWF oluyi-pathological, ngoba lusebenza kuphela lapho i-blood clot iba yi-pathological.

Ucwaningo luhlaziye izici zama-antibody akhona e-anti-VWF futhi lwathola izici ezinhle kakhulu ze-antibody ngayinye ukubopha nokuvimba i-VWF ngaphansi kwezimo zokuqina kwe-pathological. Uma kungekho ukusabela okubi, la ma-antibody angaba khona aqala ngokuhlanganiswa abe yisakhiwo esisha segazi ukuvimbela lezi zinkinga ezingaba khona.

Odokotela okwamanje babhekene nokulinganisela okubucayi phakathi kokusebenza kahle kwemithi kanye nemiphumela emibi yokopha. I-antibody eyakhiwe yaklanywa ngokukhethekile futhi ngeke iphazamise ukujiya kwegazi okuvamile, ngakho-ke kunethemba lokuthi ingasebenzisa umthamo ophezulu nophumelelayo kakhulu kunezindlela zokwelapha ezikhona.

Lolu cwaningo olwenziwe ngaphakathi kwe-vitro lwenziwe ngamasampula egazi lomuntu. Isinyathelo esilandelayo ukuhlola ukusebenza kahle kwe-antibody kumodeli yesilwane esincane ukuze kuqondwe ukuthi isebenza kanjani ohlelweni oluyinkimbinkimbi lokuphila olufana nolwethu.

Inkomba: UThomas Hoefer nabanye. Ukuqondisa i-gradient ye-shear esebenzayo i-von Willebrand factor yi-antibody entsha ye-single-chain A1 kunciphisa ukwakheka kwe-thrombus e-occlusive in vitro, Haematologica (2020).