Ukuphazamiseka kokujiya kwegazi kusongela impilo, ngoba ukuphazamiseka kokujiya kwegazi kubangelwa yizizathu ezahlukahlukene ezibangela ukuphazamiseka kokusebenza kokujiya komzimba womuntu. Ngemva kokungasebenzi kahle kokujiya kwegazi, kuzovela uchungechunge lwezimpawu zokopha. Uma kwenzeka ukopha okukhulu ngaphakathi kobuchopho, kunengozi enkulu yokuphila. Ngenxa yokuthi kunezifo eziningi ezibangelwa ukungasebenzi kahle kokujiya kwegazi, okuvamile kakhulu ukwelashwa yi-hemophilia A, i-hemophilia B, i-vascular hemophilia, ukuntuleka kwe-vitamin K, ukusabalalisa imithambo yegazi ku-vitamin. Lezi zifo zingabangela izifo zokungasebenzi kahle kokujiya kwegazi. Uma kuyisiguli esine-hemophilia A enzima, kukhona ukuthambekela kokopha okusobala ngokwako. Ngemva kokulimala okuncane, kulula ukubangela ukopha. Uma iziguli ezine-hemophilia A enzima zihlushwa ukujiya kwegazi, kulula ukubangela ukopha okukhulu kwe-craniocerebral, okusongela impilo yesiguli. Ngaphezu kwalokho, ukujiya okukhulu kwemithambo yegazi yangaphakathi, ngenxa yokusetshenziswa kanye nokungasebenzi kahle kokujiya kwezinto ezahlukahlukene zokujiya kwegazi, nakho kuthambekele ekujiya okukhulu kwegazi, okuholela ekufeni kwesiguli kusenesikhathi.