Vuto la kutsekeka kwa magazi ndikuyika moyo pachiwopsezo, chifukwa kusokonezeka kwa coagulation kumachitika pazifukwa zosiyanasiyana zomwe zimayambitsa kusokonezeka kwa thupi la munthu.Pambuyo coagulation kukanika, mndandanda wa zizindikiro za magazi zidzachitika.Ngati kwambiri intracranial kukha mwazi kumachitika, pali ngozi yaikulu ya moyo.Chifukwa pali matenda ambiri obwera chifukwa cha kukomoka kwa coagulation, matenda odziwika bwino ndi hemophilia A, haemophilia B, vascular hemophilia, kusowa kwa vitamini K, kufalikira kwa mitsempha yamagazi mu vitamini Matendawa amatha kuyambitsa matenda osokonekera.Ngati ndi wodwala kwambiri hemophilia A, pali chizolowezi chodziwikiratu magazi okha.Pambuyo povulala pang'ono, ndikosavuta kuyambitsa magazi.Ngati odwala omwe ali ndi vuto la hemophilia A akuvutika ndi zoopsa, ndikosavuta kuyambitsa magazi amtundu wa craniocerebral, omwe amaika moyo wa wodwalayo pachiswe.Komanso, kwambiri mkati mitsempha ya magazi coagulation, chifukwa cha mowa ndi coagulation kukanika zosiyanasiyana coagulation zinthu, komanso sachedwa kwambiri magazi, zikubweretsa mwamsanga imfa ya wodwalayo.