Abaphandi kwiYunivesithi yaseMonash bayile i-antibody entsha enokuthintela iproteni ethile egazini ukuthintela i-thrombosis ngaphandle kwemiphumo emibi enokubakho. Le antibody inokuthintela i-thrombosis ye-pathological, enokubangela ukuhlaselwa yintliziyo kunye nokubetha kwentliziyo ngaphandle kokuchaphazela ukusebenza okuqhelekileyo kokujiya kwegazi.

Ukuhlaselwa sisifo sentliziyo kunye nestroke kusezezona zinto ziphambili ezibangela ukufa nokugula kwihlabathi liphela. Unyango lwangoku lwe-antithrombotic (anticoagulant) lunokubangela iingxaki ezinkulu zokopha kuba lukwaphazamisana nokuqina kwegazi okuqhelekileyo. I-4-5 yezigulana ezifumana unyango lwe-antiplatelet ziseneziganeko zentliziyo eziphindaphindayo.

Ke ngoko, amayeza akhoyo okulwa neeplatelet awakwazi ukusetyenziswa kwiidosi ezinkulu. Ke ngoko, ukusebenza kakuhle kwezonyango kusadanisa, kwaye unyango lwexesha elizayo kufuneka luhlengahlengiswe ngokusisiseko.

Indlela yophando kukuqala ngokufumanisa umahluko webhayoloji phakathi kokujiya okuqhelekileyo kunye nokujiya kwe-pathological, kwaye kufunyaniswe ukuba i-von Willebrand factor (VWF) itshintsha iipropati zayo xa kwakheka i-thrombus eyingozi. Olu phononongo luyile i-antibody efumanisa kwaye ivale olu hlobo lwe-pathological lwe-VWF, kuba isebenza kuphela xa i-blood clot iba yi-pathological.

Olu phononongo luhlalutye iimpawu zee-anti-VWF antibodies ezikhoyo kwaye lufumanise ezona mpawu zibalaseleyo ze-antibody nganye yokubopha nokuvala i-VWF phantsi kweemeko ze-pathological coagulation. Ukuba akukho ziphumo zimbi, ezi antibodies ezinokubakho ziqala zidityaniswe zibe yisakhiwo esitsha segazi ukuthintela ezi ngxaki zinokubakho.

Oogqirha okwangoku bajongene nolungelelwano olubuthathaka phakathi kokusebenza kakuhle kwamayeza kunye nemiphumo emibi yokopha. I-antibody eyenziweyo yenzelwe ngokukodwa kwaye ayizukuphazamisana nokujiya kwegazi okuqhelekileyo, ngoko ke kunethemba lokuba ingasebenzisa idosi ephezulu nesebenzayo ngakumbi kunezonyango ezikhoyo.

Olu phononongo lwenziwe nge-in vitro ngeesampuli zegazi lomntu. Inyathelo elilandelayo kukuvavanya ukusebenza kakuhle kwe-antibody kwimodeli yesilwanyana esincinci ukuze kuqondwe indlela esebenza ngayo kwinkqubo yokuphila enzima efana neyethu.

Isalathiso: UThomas Hoefer et al. Ukujolisa kwi-shear gradient esebenzayo ye-von Willebrand factor yi-antibody entsha ye-single-chain A1 kunciphisa ukwakheka kwe-occlusive thrombus kwi-vitro, Haematologica (2020).