Ingxaki yokunqanda igazi isongela ubomi, kuba iingxaki zokunqanda igazi zibangelwa zizizathu ezahlukeneyo ezibangela ukuphazamiseka komsebenzi womzimba womntu wokunqanda igazi. Emva kokungasebenzi kakuhle kokwaluphala kwegazi, kuza kubakho uthotho lweempawu zokopha. Ukuba kuvela ukopha okukhulu ngaphakathi kwentloko, kukho ingozi enkulu yobomi. Ngenxa yokuba kukho izifo ezininzi ezibangelwa kukungasebenzi kakuhle kokwaluphala kwegazi, imeko eqhelekileyo yeklinikhi yi-hemophilia A, i-hemophilia B, i-vascular hemophilia, ukunqongophala kwe-vitamin K, ukusasaza imithambo yegazi kwi-vitamin Ezi zifo zinokubangela izifo zokwaluphala kwegazi. Ukuba sisigulana esine-hemophilia A enzima, kukho ukuthambekela kokopha okucacileyo ngokwaso. Emva kokwenzakala okuncinci, kulula ukubangela ukopha igazi. Ukuba izigulana ezine-hemophilia A enzima zinengxaki yokwenzakala, kulula ukubangela ukopha kwegazi okukhulu kwe-craniocerebral, okubeka ubomi besigulana emngciphekweni. Ukongeza, ukunqanda kwegazi okukhulu kwangaphakathi, ngenxa yokusetyenziswa kunye nokungasebenzi kakuhle kwezinto ezahlukeneyo zokunqanda igazi, kukwakho nokuthambekela kokopha kakhulu, okukhokelela ekufeni kwangoko kwesigulana.