Vaongorori vepaMonash University vakagadzira mushonga mutsva unogona kudzivirira puroteni muropa kudzivirira thrombosis pasina migumisiro yakaipa. Mushonga uyu unogona kudzivirira thrombosis, iyo inogona kukonzera kurwiswa kwemoyo nestroke pasina kukanganisa mashandiro eropa akajairika.

Kurwara nemwoyo nestroke zvichiri kukonzera rufu nezvirwere pasi rose. Mishonga iripo yekudzivirira ropa kubva muropa (anticoagulant) inogona uye inokonzera matambudziko makuru ekubuda ropa nekuti inokanganisawo kugwinha kweropa kwakajairika. Zvikamu zvina muzvishanu zvevarwere vanorapwa neantiplatelet therapy vachiri nezviitiko zvemwoyo zvinoramba zvichiitika.

Saka, mishonga iripo yekudzivirira maplatelet haigone kushandiswa muhuwandu hwakawanda. Saka, kushanda zvakanaka kwekiriniki kuchiri kusafadza, uye marapirwo emangwana anofanira kugadziriswa patsva.

Nzira yekutsvagisa ndeyekutanga kuona musiyano wezvehupenyu pakati pekugwamba kweropa kwakajairika negwamba reropa, uye kuona kuti von Willebrand factor (VWF) inochinja hunhu hwayo kana thrombus ine njodzi yaumbwa. Chidzidzo ichi chakagadzira antibody inongoona nekuvhara rudzi urwu rweVWF, nekuti inoshanda chete kana gwamba reropa rava chirwere.

Chidzidzo ichi chakaongorora hunhu hwema antibodies aripo ekudzivirira VWF uye chakaona hunhu hwakanakisa hwe antibody yega yega yekubatanidza nekudzivirira VWF pasi pemamiriro ekugwinya kweropa. Kana pasina chero maitiro asina kunaka, aya ma antibodies anogona kutanga abatanidzwa kuita chimiro chitsva cheropa kudzivirira matambudziko aya anogona kuitika.

Vanachiremba parizvino vari kutarisana nekuenzana pakati pekushanda kwemushonga uye migumisiro yekubuda ropa. Antibody yakagadzirwa nemazvo uye haizokanganisi kugadzika kweropa, saka zvinotarisirwa kuti inogona kushandisa mushonga wakakwira uye unoshanda kupfuura mishonga iripo.

Chidzidzo ichi chakaitwa neropa revanhu. Danho rinotevera ndere kuyedza kushanda kweantibody mumhando yemhuka diki kuti tinzwisise mashandiro ayo muhurongwa hwakaoma hwekurarama hwakafanana nehwedu.

Reference： Thomas Hoefer nevamwe. Kutarisa shear gradient activated von Willebrand factor ne single-chain antibody itsva A1 kunoderedza occlusive thrombus formation in vitro, Haematologica (2020).