Ofufuza ku Monash University apanga antibody yatsopano yomwe ingalepheretse puloteni inayake m'magazi kuti iteteze thrombosis popanda zotsatirapo zoyipa. Antibody iyi imatha kuletsa thrombosis, yomwe ingayambitse matenda a mtima ndi sitiroko popanda kusokoneza magwiridwe antchito abwinobwino a magazi.

Matenda a mtima ndi sitiroko akadali zifukwa zazikulu zomwe zimayambitsa imfa ndi matenda padziko lonse lapansi. Mankhwala omwe alipo pano a antithrombotic (anticoagulant) angayambitse mavuto aakulu chifukwa amasokoneza magazi kuundana bwino. Magawo anayi mwa asanu a odwala omwe amalandira chithandizo cha antiplatelet amakhala ndi matenda a mtima omwe amabwerezabwereza.

Chifukwa chake, mankhwala omwe alipo a antiplatelet sangagwiritsidwe ntchito pamlingo waukulu. Chifukwa chake, mphamvu yachipatala ikadali yokhumudwitsa, ndipo chithandizo chamtsogolo chiyenera kusinthidwa kwambiri.

Njira yofufuzira ndiyo choyamba kudziwa kusiyana kwa zamoyo pakati pa kugawanika kwa magazi ndi kugawanika kwa magazi, ndikupeza kuti von Willebrand factor (VWF) imasintha mawonekedwe ake pamene magazi oopsa a thrombus apangidwa. Kafukufukuyu adapanga antibody yomwe imangozindikira ndikuletsa mtundu uwu wa VWF, chifukwa imagwira ntchito pokhapokha magazi akagawanika.

Kafukufukuyu adasanthula makhalidwe a ma antibodies omwe alipo a anti-VWF ndipo adapeza makhalidwe abwino kwambiri a antibody iliyonse kuti amange ndikuletsa VWF pansi pa matenda otsekeka. Ngati palibe zotsatirapo zilizonse zoyipa, ma antibodies amenewa amayamba kuphatikizidwa kukhala kapangidwe katsopano ka magazi kuti apewe mavuto omwe angakhalepo.

Madokotala pakadali pano akukumana ndi kusiyana koyenera pakati pa mphamvu ya mankhwala ndi zotsatirapo zoyipa za kutuluka magazi. Antibody yopangidwa mwaluso idapangidwa mwapadera ndipo sidzasokoneza kugayika kwa magazi mwachibadwa, kotero tikuyembekeza kuti ingagwiritse ntchito mlingo wokwera komanso wogwira mtima kuposa mankhwala omwe alipo kale.

Kafukufukuyu wa mu vitro adachitika ndi zitsanzo za magazi a anthu. Gawo lotsatira ndikuyesa momwe antibody imagwirira ntchito mu chitsanzo cha nyama yaying'ono kuti timvetse momwe imagwirira ntchito mu dongosolo lovuta la zamoyo lofanana ndi lathu.

Buku Lothandizira: Thomas Hoefer ndi ena. Kuyang'anira shear gradient yomwe imayambitsa von Willebrand factor ndi antibody yatsopano ya unyolo umodzi A1 kumachepetsa kupangika kwa thrombus mu vitro, Haematologica (2020).