Ahakoa he pai, he kino rānei te toto totoka, kāore e kitea te toto totoka. He wā noa te toto totoka. Ki te tere rawa, ki te puhoi rawa rānei, ka kino ki te tinana tangata.

Ka noho te toto totoka i roto i tētahi awhe noa, kia kore ai e puta he toto me te hanganga thrombus i roto i te tinana o te tangata. Mēnā he tere rawa te toto totoka, he tohu tēnei kei roto te tinana o te tangata i tētahi āhua totoka nui rawa, ā, he ngāwari te puta o ngā mate pūnaha toto me ngā mate pūnaha roro, pērā i te mate roro me te mate ngakau, te mate toto uaua o ngā pito o raro me ētahi atu mate. Mēnā he puhoi rawa te totoka o te tūroro, tera pea ka pāngia e te ngoikore o te toto totoka, ka ngāwari ki te pāngia e ngā mate totoka, pērā i te hemophilia, ā, i ngā wā kino, ka puta he ngoikore o ngā hononga me ētahi atu pānga kino.

Ko te pai o te mahi a te thrombin e tohu ana kei te pai te mahi a ngā pereti toto, ā, he tino hauora hoki. Ko te toto totoka e pā ana ki te tukanga o te toto e huri ana mai i te āhua rere ki te āhua tiēre, ā, ko tōna uho ko te tukanga o te huri i te fibrinogen wairewa ki te fibrinogen kore wairewa i roto i te toto toto. I roto i te tikanga whaiti, ina pakaru ngā oko toto, ka whakaputa te tinana i ngā mea totoka, ka whakahohehia hei whakaputa i te thrombin, ka huri i te fibrinogen hei fibrin, ā, ka whakatairanga i te toto totoka. Ko te totoka i te nuinga o te wā kei roto hoki i te mahi a te pereti totoka.

Ko te whakatau mēnā he pai te toto totoka, he kore rānei, ko te nuinga o te wā mā roto i ngā whakamātautau toto me ngā whakamātautau taiwhanga. Ko te ngoikore o te toto totoka e pā ana ki ngā raruraru o ngā āhuatanga totoka, te iti o te rahinga, te mahi rerekē rānei, me te raupapa o ngā tohu totoka. Ka puta pea te toto totoka ohorere, ā, ka kitea te purpura, te ecchymosis, te epistaxis, te toto kapia, me te hematuria i runga i te kiri me ngā kiriuhi mucous. I muri i te whara, i te pokanga rānei, ka piki ake te nui o te toto ka roa ake te wā totoka. Mā te kitenga o te wā prothrombin, te wā prothrombin kua whakahohehia me ētahi atu mea, ka kitea kāore i te pai te mahi totoka, ā, me whakamārama te take o te tātaritanga.