Cov kws tshawb fawb ntawm Monash University tau tsim ib lub tshuaj tiv thaiv kab mob tshiab uas tuaj yeem tiv thaiv ib qho protein tshwj xeeb hauv cov ntshav kom tiv thaiv kev mob thrombosis yam tsis muaj kev phiv. Lub tshuaj tiv thaiv kab mob no tuaj yeem tiv thaiv kev mob thrombosis, uas tuaj yeem ua rau mob plawv thiab mob hlwb yam tsis cuam tshuam rau kev ua haujlwm ntawm cov ntshav txhaws.

Kev mob plawv thiab mob hlwb tseem yog cov ua rau neeg tuag thiab mob hnyav thoob ntiaj teb. Cov kev kho mob antithrombotic (anticoagulant) tam sim no tuaj yeem ua rau muaj teeb meem loj heev los ntshav vim tias lawv kuj cuam tshuam rau kev ntshav khov. Plaub feem tsib ntawm cov neeg mob uas tau txais kev kho mob antiplatelet tseem muaj cov teeb meem plawv rov tshwm sim.

Yog li ntawd, cov tshuaj antiplatelet uas twb muaj lawm tsis tuaj yeem siv ntau ntau. Yog li ntawd, qhov ua tau zoo ntawm kev kho mob tseem tsis tau zoo, thiab kev kho mob yav tom ntej yuav tsum tau hloov kho dua tshiab.

Txoj kev tshawb fawb yog thawj zaug txiav txim siab qhov sib txawv ntawm cov ntshav coagulation ib txwm muaj thiab cov ntshav coagulation pathological, thiab pom tias von Willebrand factor (VWF) hloov nws cov khoom thaum muaj cov ntshav thrombus txaus ntshai. Txoj kev tshawb fawb tau tsim ib qho tshuaj tiv thaiv kab mob uas tsuas yog ntes thiab thaiv cov kab mob VWF no, vim nws tsuas yog ua haujlwm thaum cov ntshav txhaws dhau los ua kab mob.

Txoj kev tshawb fawb no tau tshuaj xyuas cov yam ntxwv ntawm cov tshuaj tiv thaiv kab mob VWF uas twb muaj lawm thiab txiav txim siab txog cov yam ntxwv zoo tshaj plaws ntawm txhua cov tshuaj tiv thaiv kab mob los khi thiab thaiv VWF nyob rau hauv cov xwm txheej pathological coagulation. Yog tias tsis muaj kev tsis haum tshuaj, cov tshuaj tiv thaiv kab mob no yuav raug muab sib xyaw ua ke ua cov qauv ntshav tshiab kom tiv thaiv cov teeb meem no.

Cov kws kho mob tam sim no ntsib teeb meem sib npaug ntawm cov tshuaj zoo thiab cov kev mob tshwm sim los ntawm kev los ntshav. Cov tshuaj tiv thaiv kab mob no tau tsim tshwj xeeb thiab yuav tsis cuam tshuam rau cov ntshav coagulation ib txwm muaj, yog li nws tau cia siab tias nws tuaj yeem siv cov tshuaj ntau dua thiab zoo dua li cov kev kho mob uas twb muaj lawm.

Qhov kev tshawb fawb hauv vitro no tau ua nrog cov qauv ntshav tib neeg. Kauj ruam tom ntej yog sim qhov ua tau zoo ntawm cov tshuaj tiv thaiv kab mob hauv tus qauv tsiaj me me kom nkag siab tias nws ua haujlwm li cas hauv lub cev muaj sia nyob zoo ib yam li peb tus kheej.

Siv: Thomas Hoefer et al. Kev tsom mus rau shear gradient activated von Willebrand factor los ntawm cov tshuaj antibody A1 tshiab txo cov occlusive thrombus tsim hauv vitro, Haematologica (2020).