I loko o ke ola, hiki i nā kānaka ke ʻeha a kahe ke koko i kēlā me kēia manawa.Ma lalo o nā kūlana maʻamau, inā ʻaʻole mālama ʻia kekahi mau ʻeha, e hoʻopaʻa mālie ke koko, e hoʻōki i ke kahe ʻana iā ia iho, a ma hope e waiho i nā ʻōpala koko.No ke aha kēia?He aha nā mea i hana nui i kēia hana?A laila, e ʻimi pū kākou i ka ʻike o ke koko coagulation!

E like me kā mākou e ʻike ai, ke kahe mau nei ke koko i loko o ke kino o ke kanaka ma lalo o ke kaomi ʻana o ka puʻuwai e lawe i ka oxygen, protein, wai, electrolytes a me nā kalapona e pono ai ke kino.Ma lalo o nā kūlana maʻamau, kahe ke koko i loko o nā kīʻaha koko.Ke hoʻopōʻino ʻia nā kīʻaha koko, e hoʻōki ke kino i ke koko a me ka hoʻopaʻa ʻana ma o ke ʻano o nā hopena.ʻO ka coagulation maʻamau a me ka hemostasis o ke kino kanaka e hilinaʻi nui ʻia i ke ʻano a me ka hana o ka pā kīʻaha koko paʻa, ka hana maʻamau o nā kumu coagulation, a me ka maikaʻi a me ka nui o nā platelets kūpono.

Ma lalo o nā kūlana maʻamau, ua hoʻonohonoho ʻia nā platelets ma nā paia o loko o nā capillaries e mālama i ka pono o nā paia kīʻaha koko.I ka wā e poino ai nā kīʻaha koko, hoʻomaka mua ka ʻoki ʻana, e pili ana nā paia o nā kīʻaha koko ma ka ʻaoʻao i poino kekahi i kekahi, e emi ai ka ʻeha a e hoʻolohi i ke kahe koko.I ka manawa like, pili nā platelets, hōʻuluʻulu a hoʻokuʻu i nā mea i loko o ka ʻāpana i hōʻino ʻia, e hana ana i ka thrombus platelet kūloko, e pale ana i ka ʻeha.ʻO ka hemostasis o nā kīʻaha koko a me nā platelets i kapa ʻia he hemostasis mua, a ʻo ke kaʻina hana o ka hoʻokumu ʻana i ka fibrin clot ma ka wahi i ʻeha ma hope o ka hoʻāla ʻana o ka ʻōnaehana coagulation e ālai i ka ʻeha i kapa ʻia ʻo ka mīkini hemostatic lua.

ʻO ke kikoʻī, pili ka coagulation koko i ke kaʻina hana e hoʻololi ai ke koko mai kahi moku kahe i kahi moku gel kahe ʻole.ʻO ke ʻano o ka coagulation ʻo ia ka hoʻāla ʻia ʻana o nā mea coagulation e ka enzymolysis, a ma hope ua hoʻokumu ʻia ka thrombin e hana i kahi fibrin clot.Hoʻokomo pinepine ʻia ke kaʻina hana coagulation i ʻekolu ala, ala coagulation endogenous, ala coagulation exogenous a me ke ala coagulation maʻamau.

1) Hoʻomaka ʻia ke ala coagulation endogenous e ka coagulation factor XII ma o ka hopena pili.Ma o ka ho'āla ʻana a me ka hopena o nā ʻano kumu coagulation, ua hoʻololi hope ʻia ka prothrombin i thrombin.Hoʻololi ʻo Thrombin i ka fibrinogen i fibrin e hoʻokō i ke kumu o ka coagulation koko.

2) ʻO ke ala coagulation exogenous e pili ana i ka hoʻokuʻu ʻana i kāna kumu kikoʻī ponoʻī, e koi ana i kahi manawa pōkole no ka coagulation a me ka pane wikiwiki.

Ua hōʻike nā haʻawina i ke ala coagulation endogenous a me ke ala coagulation exogenous hiki ke hoʻoikaika a hoʻoikaika ʻia.

3) ʻO ke ala coagulation maʻamau e pili ana i ka pae coagulation maʻamau o ka ʻōnaehana coagulation endogenous a me ka ʻōnaehana coagulation exogenous, ʻo ia ka mea nui i ʻelua mau pae o ka thrombin generation a me ka hoʻokumu ʻana o fibrin.

ʻO ka mea i kapa ʻia he hemostasis a me ka pōʻino moku koko, ka mea e hoʻāla ai i ke ala coagulation exogenous.ʻAʻole maopopo loa ka hana physiological o ke ala coagulation endogenous i kēia manawa.Eia nō naʻe, ʻoiaʻiʻo e hiki ke hoʻāla ʻia ke ala coagulation koko endogenous i ka wā e hoʻopili ai ke kino kanaka me nā mea hana, ʻo ia hoʻi, hiki i nā mea ola ke kumu i ka coagulation koko i loko o ke kino kanaka, a ua lilo kēia ʻano i mea keakea nui i ka implantation o na laau lapaau iloko o ke kino kanaka.

ʻO nā mea kūpono ʻole a i ʻole nā ​​mea keakea i kekahi kumu coagulation a i ʻole loulou i ke kaʻina coagulation e hoʻokau i nā abnormalities a i ʻole nā ​​​​hana ʻole i ke kaʻina coagulation holoʻokoʻa.Hiki ke ʻike ʻia he hana paʻakikī a paʻakikī ka coagulation koko i loko o ke kino o ke kanaka, kahi mea nui i ka mālama ʻana i ko mākou ola.