I ke ola, e kuʻi a kahe ke koko o nā kānaka i kēlā me kēia manawa. Ma lalo o nā kūlana maʻamau, inā ʻaʻole mālama ʻia kekahi mau ʻeha, e hoʻopili mālie ke koko, e hoʻōki i ke kahe ʻana ma kāna iho, a waiho i nā ʻōpala koko. No ke aha mai kēia? He aha nā mea i hoʻokani i kahi kuleana koʻikoʻi i kēia kaʻina hana? A laila, e ʻimi pū kākou i ka ʻike o ke kāpili ʻana o ke koko!

E like me kā kākou e ʻike nei, ke kaʻa mau nei ke koko i loko o ke kino o ke kanaka ma lalo o ke kaomi ʻana o ka puʻuwai e lawe i ka oxygen, ka protein, ka wai, nā electrolytes a me nā carbohydrates e pono ai ke kino. Ma lalo o nā kūlana maʻamau, ke kahe nei ke koko i loko o nā kīʻaha koko. Ke hōʻino ʻia nā kīʻaha koko, e hoʻōki ke kino i ke kahe koko a me ka clotting ma o kekahi mau hopena. ʻO ke coagulation maʻamau a me ka hemostasis o ke kino o ke kanaka e hilinaʻi nui ʻia i ke ʻano a me ka hana o ka paia o nā kīʻaha koko i hoʻopaʻa ʻia, ka hana maʻamau o nā mea coagulation, a me ke ʻano a me ka nui o nā platelets maikaʻi.

Ma lalo o nā kūlana maʻamau, hoʻonohonoho ʻia nā platelets ma nā paia o loko o nā capillaries e mālama i ke kūpaʻa o nā paia o ke kīʻaha koko. Ke hōʻino ʻia nā kīʻaha koko, hana mua ʻia ka ʻūlū ʻana, e hoʻokokoke ana nā paia o nā kīʻaha koko ma ka ʻāpana i hōʻino ʻia kekahi i kekahi, e hoʻemi ana i ka ʻeha a hoʻolohi i ke kahe ʻana o ke koko. I ka manawa like, pili nā platelets, hōʻuluʻulu a hoʻokuʻu i nā mea i loko o ka ʻāpana i hōʻino ʻia, e hana ana i nā thrombus platelet kūloko, e ālai ana i ka ʻeha. ʻO ka hemostasis o nā kīʻaha koko a me nā platelets ua kapa ʻia ʻo ka hemostasis mua, a ʻo ke kaʻina hana o ka hana ʻana i kahi clot fibrin ma kahi i ʻeha ma hope o ka hoʻāla ʻana o ka ʻōnaehana coagulation e ālai i ka ʻeha ua kapa ʻia ʻo ka ʻano hemostatic lua.

ʻO ke kikoʻī, ʻo ke kāpili ʻana o ke koko e pili ana i ke kaʻina hana e loli ai ke koko mai kahi mokuʻāina kahe i kahi mokuʻāina gel ʻaʻole kahe. ʻO ke kāpili ʻana ke ʻano o ka hoʻāla ʻia ʻana o kahi moʻo o nā mea coagulation e ka enzymolysis, a ma hope ua hoʻokumu ʻia ka thrombin e hana i kahi clot fibrin.Hoʻokomo pinepine ke kaʻina hana coagulation i ʻekolu mau ala, ke ala coagulation endogenous, ke ala coagulation exogenous a me ke ala coagulation maʻamau.

1) Hoʻomaka ʻia ke ala coagulation endogenous e ka coagulation factor XII ma o kahi hopena pili. Ma o ka hoʻoulu ʻana a me ka hopena o nā ʻano coagulation like ʻole, ua hoʻololi hope ʻia ka prothrombin i thrombin. Hoʻololi ʻo Thrombin i ka fibrinogen i fibrin e hoʻokō i ke kumu o ke coagulation koko.

2) ʻO ke ala coagulation exogenous e pili ana i ka hoʻokuʻu ʻana o kāna kumu kiko ponoʻī, kahi e pono ai kahi manawa pōkole no ka coagulation a me ka pane wikiwiki.

Ua hōʻike ʻia nā haʻawina e hiki ke hoʻāla ʻia ke ala coagulation endogenous a me ke ala coagulation exogenous a hoʻāla ʻia kekahi i kekahi.

3) ʻO ke ala coagulation maʻamau e pili ana i ke kahua coagulation maʻamau o ka ʻōnaehana coagulation endogenous a me ka ʻōnaehana coagulation exogenous, ʻo ia hoʻi nā pae ʻelua o ka hanauna thrombin a me ka hoʻokumu ʻana o fibrin.

ʻO ka mea i kapa ʻia ʻo hemostasis a me ka hōʻino ʻana o nā kīʻaha koko, ka mea e hoʻoulu ai i ke ala coagulation exogenous. ʻAʻole maopopo loa ka hana physiological o ke ala coagulation endogenous i kēia manawa. Eia nō naʻe, he mea maopopo e hiki ke hoʻāla ʻia ke ala coagulation koko endogenous i ka wā e launa pū ai ke kino kanaka me nā mea hana, ʻo ia hoʻi hiki i nā mea olaola ke hoʻoulu i ka coagulation koko i loko o ke kino kanaka, a ua lilo kēia hanana i mea keakea nui i ka hoʻokomo ʻana o nā mea lapaʻau i loko o ke kino kanaka.

ʻO nā mea ʻē aʻe a i ʻole nā ​​mea keakea i kekahi kumu coagulation a i ʻole loulou i ke kaʻina hana coagulation e hana i nā mea ʻē aʻe a i ʻole nā ​​​​​​hana ʻole i ke kaʻina hana coagulation holoʻokoʻa. Hiki ke ʻike ʻia he hana paʻakikī a palupalu ke coagulation koko i loko o ke kino o ke kanaka, kahi e hoʻokani ai i kahi kuleana koʻikoʻi i ka mālama ʻana i ko mākou ola.