Masu bincike a Jami'ar Monash sun tsara wani sabon maganin rigakafi wanda zai iya hana wani takamaiman furotin a cikin jini don hana thrombosis ba tare da yuwuwar illa ba. Wannan maganin rigakafi na iya hana thrombosis na cututtukan da ke haifar da bugun zuciya da bugun jini ba tare da shafar aikin daidaita jini ba.

Ciwon zuciya da shanyewar jiki sun kasance manyan abubuwan da ke haifar da mace-mace da rashin lafiya a duk duniya. Magungunan hana zubar jini na yanzu (anticoagulant) na iya kuma suna haifar da manyan matsaloli na zubar jini saboda suna kuma hana zubar jini yadda ya kamata. Kashi huɗu cikin biyar na marasa lafiya da ke shan maganin hana zubar jini har yanzu suna da abubuwan da ke faruwa a zuciya da jijiyoyin jini da ke sake faruwa.

Saboda haka, ba za a iya amfani da magungunan hana platelet da ake da su a allurai masu yawa ba. Saboda haka, tasirin asibiti har yanzu abin takaici ne, kuma ana buƙatar sake fasalin magunguna na gaba.

Hanyar bincike ita ce a fara tantance bambancin halitta tsakanin coagulation na yau da kullun da coagulation na pathological, sannan a gano cewa von Willebrand factor (VWF) yana canza halayensa lokacin da aka samar da thrombus mai haɗari. Binciken ya tsara wani maganin rigakafi wanda ke gano kuma yana toshe wannan nau'in VWF na pathological kawai, saboda yana aiki ne kawai lokacin da gudan jini ya zama cuta.

Binciken ya yi nazarin halayen ƙwayoyin rigakafi na anti-VWF da ke akwai kuma ya tantance mafi kyawun halaye na kowace ƙwayar rigakafi don ɗaurewa da toshe VWF a ƙarƙashin yanayin coagulation na cuta. Idan babu wani mummunan sakamako, ana haɗa waɗannan ƙwayoyin rigakafi na farko zuwa sabon tsarin jini don hana waɗannan rikice-rikicen.

Likitoci a halin yanzu suna fuskantar daidaito mai zurfi tsakanin tasirin magani da kuma illolin zubar jini. An tsara maganin rigakafi na musamman kuma ba zai tsoma baki ga yadda jini ke aiki ba, don haka ana fatan zai iya amfani da magani mafi girma da inganci fiye da magungunan da ake da su.

An gudanar da wannan binciken a cikin vitro tare da samfuran jinin ɗan adam. Mataki na gaba shine a gwada ingancin maganin rigakafi a cikin ƙaramin samfurin dabba don fahimtar yadda yake aiki a cikin tsarin rayuwa mai rikitarwa irin namu.

Nassoshi: Thomas Hoefer et al. Yin amfani da fasahar rage zafi ta hanyar amfani da fasahar von Willebrand factor ta hanyar amfani da sabuwar fasahar antibody mai sarkar guda ɗaya A1 yana rage samuwar thrombus mai ɓoyewa a cikin vitro, Haematologica (2020).