Isikhathi se-Thrombin (TT) nesikhathi se-prothrombin (PT) yizinkomba zokubona ukusebenza kwe-coagulation, umehluko phakathi kwakho kokubili usekutholeni izici ezihlukene zokuhlangana.

Isikhathi se-Thrombin (TT) siyinkomba yesikhathi esidingekayo ukuze kutholwe ukuguqulwa kwe-plasma prothrombin ibe yi-thrombin.Ngokuyinhloko isetshenziselwa ukuhlola isimo somsebenzi we-fibrinogen kanye nezici ze-coagulation I, II, V, VIII, X kanye ne-XIII ku-plasma.Phakathi nenqubo yokutholwa, inani elithile lezicubu ze-prothrombin ne-calcium ions zengezwa ukuze kuguqulwe i-prothrombin ku-plasma ibe yi-thrombin, futhi isikhathi sokuguqulwa siyalinganiswa, okuyinani le-TT.

Isikhathi se-Prothrombin (PT) yinkomba yokuthola umsebenzi wezici ze-coagulation yegazi ngaphandle kwesistimu ye-coagulation yegazi.Phakathi nenqubo yokuthola, inani elithile lokubunjwa kwe-coagulation factor (njenge-coagulation factor II, V, VII, X kanye ne-fibrinogen) yengezwa ukuze kusebenze uhlelo lwe-coagulation, futhi isikhathi sokwakheka kwehlule siyalinganiswa, okuyinani le-PT.Inani le-PT libonisa isimo somsebenzi we-coagulation factor ngaphandle kwesistimu ye-coagulation.

Kumele kuqashelwe ukuthi kokubili amanani e-TT kanye ne-PT ayizinkomba ezivame ukusetshenziswa ukulinganisa umsebenzi we-coagulation, kodwa lezi ezimbili azikwazi ukufaka esikhundleni somunye nomunye, futhi izinkomba zokuthola ezifanele kufanele zikhethwe ngokuvumelana nesimo esithile.Ngesikhathi esifanayo, kufanele kuqashelwe ukuthi umehluko wezindlela zokutholwa kanye nama-reagents angase athinte ukunemba kwemiphumela, futhi ukunakwa kufanele kukhokhwe ekusebenzeni okujwayelekile ekusebenzeni komtholampilo.