I-Thrombin ingakhuthaza ukujiya kwegazi, idlale indima ekumiseni ukopha, futhi ingakhuthaza ukuphulukiswa kwamanxeba nokulungiswa kwezicubu.

I-Thrombin iyi-enzyme ebalulekile enqubweni yokujiya kwegazi, futhi iyi-enzyme eyinhloko eyaguqulwa yaba yi-fibrin ku-fibrin. Lapho imithambo yegazi yonakele, i-glycrase ikhiqizwa ngaphansi kwesenzo sama-platelet namaseli e-vascular endothelial, okukhuthaza ukuhlangana kwama-platelet kanye ne-thrombosis, ngaleyo ndlela kumise i-hemostasis. Ngaphezu kwalokho, i-coordinase ingakhuthaza futhi ukuphulukiswa kwamanxeba nokulungiswa kwezicubu, okuyisithako se-enzyme esibalulekile ekulungisweni kwezicubu.

Kufanele kuqashelwe ukuthi ukusebenza ngokweqile kwe-thrombin kungabangela nezinkinga ezifana ne-thrombosis kanye nesifo senhliziyo. Ngakho-ke, kubalulekile ukulandela ngokuqinile iseluleko sikadokotela kanye nomthamo wemithi lapho usebenzisa imithi ehlobene ne-coordinase ukuze ugweme ukusabela okubi nemiphumela emibi.

Umsebenzi we-fibrinogen ekuqaleni wawungumphumela wokukhuthaza ukuhlangana kwama-platelet ekujiya kwegazi. I-Fibrinogen ekuqaleni yayiyiprotheni ebalulekile enkambisweni yokuhlangana kwama-platelet. Umsebenzi wayo oyinhloko ukuhlangana kwama-platelet kanye ne-hemostasis, kanye nokuhlanganyela ekukhiqizweni kwama-platelet. Inani elijwayelekile le-fibrinogen lingu-2-4g/L. Ukuphakama kwezinga lokuqala le-fibrin kuhlobene kakhulu nokuvela kwezifo ze-thrombotic. Ukwanda kokwanda kwe-fibrin kungabangelwa izici zomzimba, njengokukhulelwa kanye nokuguga, noma izici ze-pathological, njengomfutho wegazi ophakeme, isifo sikashukela, isifo senhliziyo se-coronary atherosclerotic.

Izinga le-fibrin liyancishiswa, okungase kubangelwe izifo zesibindi, njenge-cirrhosis kanye ne-hepatitis ebukhali. Iziguli kudingeka ziye esibhedlela ukuze zihlolwe kusenesikhathi futhi zelashwe ngaphansi kwesiqondiso sikadokotela.