Ixesha leThrombin (TT) kunye nexesha leprothrombin (PT) zizinto ezisetyenziswa kakhulu njengezalathisi zokufumanisa umsebenzi we-coagulation, umahluko phakathi kwezi zimbini ukho ekufumaneni izinto ezahlukeneyo ze-coagulation.

Ixesha leThrombin (TT) libonisa ixesha elifunekayo ukuze kufunyanwe ukuguqulwa kwe-plasma prothrombin ibe yi-thrombin. Isetyenziswa kakhulu ukuvavanya imeko yomsebenzi we-fibrinogen kunye ne-coagulation factors I, II, V, VIII, X kunye ne-XIII kwi-plasma. Ngexesha lenkqubo yokufumanisa, inani elithile le-tissue prothrombin kunye ne-calcium ions zongezwa ukuguqula i-prothrombin kwi-plasma ibe yi-thrombin, kwaye ixesha lokuguqula liyalinganiswa, elixabiso le-TT.

Ixesha le-Prothrombin (PT) sisalathisi sokufumanisa umsebenzi wezinto ezidibanisa igazi ngaphandle kwenkqubo yokuxinana kwegazi. Ngexesha lenkqubo yokufumanisa, inani elithile lezinto ezidibanisa igazi (ezifana nezinto ezidibanisa igazi II, V, VII, X kunye ne-fibrinogen) zongezwa ukuze kusebenze inkqubo yokuxinana kwegazi, kwaye ixesha lokwakheka kwe-clot liyalinganiswa, elixabiso le-PT. Ixabiso le-PT libonisa imeko yomsebenzi we-coagulation factor ngaphandle kwenkqubo yokuxinana kwegazi.

Kufuneka kuqatshelwe ukuba zombini ixabiso le-TT kunye ne-PT ziimpawu ezisetyenziswa rhoqo ukulinganisa umsebenzi wokujiya kwegazi, kodwa ezi zimbini azinakuthatha indawo enye, kwaye izibonakaliso ezifanelekileyo zokufumanisa kufuneka zikhethwe ngokwemeko ethile. Kwangaxeshanye, kufuneka kuqatshelwe ukuba umahluko kwiindlela zokufumanisa kunye nee-reagents unokuchaphazela ukuchaneka kweziphumo, kwaye kufuneka kuqwalaselwe imisebenzi eqhelekileyo kwizenzo zonyango.