I-Thrombin inokukhuthaza ukujiya kwegazi, idlale indima ekumiseni ukopha, kwaye inokukhuthaza ukuphiliswa kwamanxeba kunye nokulungiswa kwezicubu.

I-Thrombin yinto ebalulekileyo ye-enzyme kwinkqubo yokujiya kwegazi, kwaye yi-enzyme ephambili eyaguqulwa yaba yi-fibrin kwi-fibrin. Xa imithambo yegazi yonakele, i-glycrase iveliswa phantsi kwesenzo see-platelet kunye neeseli ze-vascular endothelial, ikhuthaza ukuhlanganiswa kwe-platelet kunye ne-thrombosis, ngaloo ndlela imisa i-hemostasis. Ukongeza, i-coordinase inokukhuthaza ukuphiliswa kwamanxeba kunye nokulungiswa kwezicubu, into leyo eyimfuneko kakhulu ekulungisweni kwezicubu.

Kufuneka kuqatshelwe ukuba ukusebenza kakhulu kwe-thrombin kunokubangela iingxaki ezifana ne-thrombosis kunye nesifo sentliziyo. Ke ngoko, kuyimfuneko ukulandela ngokungqongqo iingcebiso zikagqirha kunye nomthamo wamayeza xa usebenzisa amayeza anxulumene ne-coordinase ukuze uphephe iziphumo ezibi kunye nemiphumo emibi.

Umsebenzi we-fibrinogen ekuqaleni wawungumphumo wokukhuthaza ukuhlanganiswa kweeplatelet ekujikeni kwegazi. I-Fibrinogen ekuqaleni yayiyiproteni ebalulekileyo kwinkqubo yokujiya kwegazi. Umsebenzi wayo ophambili kukujiya kwegazi kunye ne-hemostasis, kunye nokubandakanyeka kwimveliso yeeplatelet. Ixabiso eliqhelekileyo le-fibrinogen yi-2-4g/L. Ukuphakama kwenqanaba lokuqala le-fibrin kunxulumene kakhulu nokwenzeka kwezifo ze-thrombotic. Ukunyuka kokunyuka kwe-fibrin kunokubangelwa zizinto zomzimba, ezifana nokukhulelwa okufike emva kwexesha kunye nobudala, okanye izinto ze-pathological, ezifana noxinzelelo lwegazi, isifo seswekile, isifo sentliziyo se-coronary atherosclerotic.

Inqanaba le-fibrin liyancitshiswa, nto leyo enokubangelwa zizifo zesibindi, ezifana ne-cirrhosis kunye ne-hepatitis ebukhali. Izigulana kufuneka ziye esibhedlele ukuze zihlolwe kwangethuba kwaye zinyangwe phantsi kwesikhokelo sikagqirha.