Thrombin inogona kukurudzira kuonda kweropa, kuita basa rekumisa kubuda kweropa, uye inogonawo kukurudzira kupora kwemaronda uye kugadzirisa maronda.

Thrombin chinhu chakakosha mukuita kwekugwamba kweropa, uye ienzyme inokosha yakatanga kushandurwa kuita fibrin mu fibrin. Kana tsinga dzeropa dzakuvara, glycrase inogadzirwa nekushanda kwemaplatelet nemasero eropa, zvichikurudzira kuungana kweplatelet uye thrombosis, nokudaro zvichimisa hemostasis. Pamusoro pezvo, coordinase inogonawo kukurudzira kupora kwemaronda uye kugadzirisa tsinga, inova chinhu chakakosha mukugadzirisa tsinga.

Zvinofanira kucherechedzwa kuti kushandiswa kwakanyanya kwe thrombin kunogonawo kukonzera matambudziko akadai se thrombosis uye chirwere chemwoyo. Nokudaro, zvakakosha kunyatsotevedzera zano rachiremba uye chiyero chemishonga paunenge uchishandisa mishonga ine chekuita ne coordinase kudzivirira kusawirirana nemigumisiro yakaipa.

Basa re fibrinogen pakutanga raive rekukurudzira kuungana kwemaplatelet muropa. Fibrinogen pakutanga yaive puroteni yakakosha mukuita kwekugwamba. Basa rayo guru kugonda uye kupwanya ropa, uye kutora chikamu mukugadzirwa kwemaplatelet. Kukosha kwakajairika kwe fibrinogen i2-4g/L. Kukwira kwehuwandu hwepakutanga hwe fibrin kwakabatana zvakanyanya nekuitika kwezvirwere zve thrombotic. Kuwedzera kwekuwedzera kwe fibrin kunogona kukonzerwa nezvinhu zvemuviri, zvakaita sepamuviri wekupedzisira uye zera, kana zvinhu zvinokonzera chirwere, zvakaita se BP, chirwere cheshuga, chirwere chemwoyo chinonzi atherosclerotic.

Huwandu hwe fibrin hunodzikira, izvo zvinogona kukonzerwa nezvirwere zvechiropa, zvakaita se cirrhosis uye hepatitis. Varwere vanofanira kuenda kuchipatara kunoongororwa nenguva uye kurapwa vachitungamirirwa nachiremba.