Thrombin ingathandize kuti magazi azigaya magazi, ingathandize kuletsa kutuluka kwa magazi, komanso ingathandize kuti mabala apole komanso kuti minofu ikonzedwenso.

Thrombin ndi chinthu chofunikira kwambiri chomwe chimagwira ntchito potseka magazi, ndipo ndi enzyme yofunika kwambiri yomwe poyamba idasinthidwa kukhala fibrin mu fibrin. Mitsempha yamagazi ikawonongeka, glycrase imapangidwa ndi ma platelet ndi maselo a endothelial a mitsempha yamagazi, zomwe zimapangitsa kuti ma platelet agwirizane komanso thrombosis ipitirire, motero imaletsa hemostasis. Kuphatikiza apo, coordinase ingathandizenso kuchiritsa mabala ndi kukonzanso minofu, yomwe ndi chinthu chofunikira kwambiri pakukonzanso minofu.

Tiyenera kudziwa kuti kuyambitsa kwambiri kwa thrombin kungayambitsenso mavuto monga thrombosis ndi matenda a mtima. Chifukwa chake, ndikofunikira kutsatira mosamalitsa upangiri wa dokotala komanso mlingo wa mankhwala mukamagwiritsa ntchito mankhwala okhudzana ndi coordinase kuti mupewe zotsatirapo zoyipa komanso zotsatirapo zoyipa.

Ntchito ya fibrinogen poyamba inali yothandiza pakulimbikitsa kusonkhana kwa ma platelet mu magazi otsekeka. Fibrinogen poyamba inali puloteni yofunika kwambiri pakutsekeka kwa magazi. Ntchito yake yayikulu ndi kutsekeka kwa magazi ndi magazi otsekeka, komanso kutenga nawo mbali popanga ma platelet. Mtengo wabwinobwino wa fibrinogen ndi 2-4g/L. Kukwera kwa kuchuluka kwa fibrin koyambirira kumagwirizana kwambiri ndi kupezeka kwa matenda opatsirana ndi magazi. Kukwera kwa kuchuluka kwa fibrin kungayambitsidwe ndi zinthu zakuthupi, monga mimba yochedwa ndi ukalamba, kapena zinthu zomwe zimayambitsa matenda, monga kuthamanga kwa magazi, matenda a shuga, matenda a mtima a atherosclerotic.

Kuchuluka kwa fibrin kumachepa, komwe kungayambitsidwe ndi matenda a chiwindi, monga cirrhosis ndi matenda a chiwindi oopsa. Odwala ayenera kupita kuchipatala kuti akafufuzidwe nthawi yake ndikuwachiza motsogozedwa ndi dokotala.