The Process Of Thrombosis


Author: Succeeder    

Thrombosis process, including 2 processes:

1. Adhesion and aggregation of platelets in blood

In the early stage of thrombosis, platelets are continuously precipitated from the axial flow and adhere to the surface of the exposed collagen fibers at the intima of damaged blood vessels. Platelets are activated by collagen and release substances such as ADP, thromboxane A2, 5-AT and platelet factor IV. , These substances have a strong effect of agglutinating platelets, so that platelets in the bloodstream continue to agglutinate locally to form a mound-shaped platelet pile. , the beginning of venous thrombosis, the head of the thrombus.

Platelets adhere to the surface of the exposed collagen fibers at the intima of the damaged blood vessel and are activated to form a hillock-like platelet stack. The hillock gradually increases and mixes with leukocytes to form a white thrombus. It has more leukocytes attached to its surface. The blood flow gradually slows down, the coagulation system is activated, and a large amount of fibrin forms a network structure, which traps more red blood cells and white blood cells to form a mixed thrombus.

2. Blood coagulation

After the white thrombus is formed, it protrudes into the vascular lumen, causing the blood flow behind it to slow down and appear a whirlpool, and a new platelet mound is formed at the whirlpool. Trabeculae, shaped like coral, have many leukocytes attached to their surface.

The blood flow between the trabeculae gradually slows down, the coagulation system is activated, and the concentration of local coagulation factors and platelet factors gradually increases, making and interweaving into a mesh structure between the trabeculae. White and white, corrugated mixed thrombus forming the body of the thrombus.

The mixed thrombus gradually increased and extended in the direction of blood flow, and finally completely blocked the blood vessel lumen, causing blood flow to stop.