Clinical application of coagulation projects in obstetrics and gynecology

Normal women experience significant changes in their coagulation, anticoagulation, and fibrinolysis functions during pregnancy and childbirth. The levels of thrombin, coagulation factors, and fibrinogen in the blood increase, while anticoagulation and fibrinolysis functions weaken, resulting in a hypercoagulable or pre thrombotic state of the blood. This physiological change provides a material basis for rapid and effective hemostasis after childbirth. However, in pathological conditions, especially when pregnancy is complicated with other diseases, the response of these physiological changes will be promoted to evolve into certain bleeding during pregnancy - thrombotic diseases.

Therefore, monitoring coagulation function during pregnancy can early detect abnormal changes in coagulation function, thrombosis, and hemostasis in pregnant women, which is of great significance for preventing and rescuing obstetric complications.