Thrombin nwere ike ịkwalite coagulation ọbara, rụọ ọrụ n'ịkwụsị ọbara ọgbụgba, ma nwee ike ịkwalite ọgwụgwọ ọnya na ndozi anụ ahụ.

Thrombin bụ ihe dị mkpa n'ime enzyme n'oge usoro coagulation ọbara, ọ bụkwa enzyme dị mkpa nke e si na mbụ gbanwee ka ọ bụrụ fibrin na fibrin. Mgbe arịa ọbara mebiri emebi, a na-emepụta glycrase n'okpuru ọrụ nke platelets na sel endothelial vascular, na-akwalite njikọta platelet na thrombosis, si otú a na-akwụsị hemostasis. Na mgbakwunye, coordinase nwekwara ike ịkwalite ọgwụgwọ ọnya na ndozi anụ ahụ, nke bụ ihe enzyme dị mkpa na ndozi anụ ahụ.

Ọ dị mkpa ịmara na oke ọrụ nke thrombin nwekwara ike ibute nsogbu dịka thrombosis na ọrịa obi. Ya mere, ọ dị mkpa ịgbaso ndụmọdụ dọkịta na usoro ọgwụ mgbe ị na-eji ọgwụ ndị metụtara koordinase iji zere mmeghachi omume ọjọọ na mmetụta ọjọọ.

Ọrụ nke fibrinogen bụ na mbụ mmetụta nke ịkwalite nchịkọta platelet na coagulation ọbara. Fibrinogen bụ na mbụ protein dị mkpa na usoro coagulation. Ọrụ ya bụ coagulation na hemostasis, yana isonye na mmepụta platelets. Uru nkịtị nke fibrinogen bụ 2-4g/L. Mmụba nke ọkwa fibrinogen mbụ nwere njikọ chiri anya na mmepe nke ọrịa thrombotic. Mmụba nke mmụba nke fibrin nwere ike ịbụ site na ihe ndị dị ndụ, dị ka afọ ime na afọ, ma ọ bụ ihe ndị na-akpata ọrịa, dị ka ọbara mgbali elu, ọrịa shuga, ọrịa obi atherosclerotic nke akwara obi.

Ọkwa fibrin na-ebelata, nke nwere ike ịbụ ọrịa imeju, dịka cirrhosis na ọrịa imeju dị oke njọ. Ndị ọrịa kwesịrị ịga ụlọ ọgwụ maka nyocha n'oge ma gwọọ ha n'okpuru nduzi nke dọkịta.