ʻAʻole loaʻa ke kāpili ʻana o ke koko inā he maikaʻi a maikaʻi ʻole paha. He manawa maʻamau ko ke kāpili ʻana o ke koko. Inā wikiwiki loa a lohi paha, e hōʻino ia i ke kino o ke kanaka.

ʻO ke kāpili ʻana o ke koko i loko o kahi pae maʻamau, i ʻole e hoʻoulu i ke kahe koko a me ka hoʻokumu ʻana o nā thrombus i loko o ke kino o ke kanaka. Inā wikiwiki loa ke kāpili ʻana o ke koko, hōʻike pinepine ia aia ke kino o ke kanaka i loko o kahi kūlana hypercoagulable, a he maʻalahi ka loaʻa ʻana o nā maʻi cardiovascular a me cerebrovascular, e like me ka cerebral infarction a me ka Myocardial infarction, ka thrombosis venous o nā ʻaoʻao haʻahaʻa a me nā maʻi ʻē aʻe. Inā lohi loa ke kāpili ʻana o ke koko o ka mea maʻi, he mea hiki ke loaʻa iā ia ka hana coagulation dysfunction, maʻalahi i nā maʻi kahe koko, e like me ka hemophilia, a i nā hihia koʻikoʻi, e waiho ia i nā deformities hui a me nā hopena ʻino ʻē aʻe.

ʻO ka hana thrombin maikaʻi e hōʻike ana e hana maikaʻi ana nā platelets a olakino loa. ʻO ke coagulation e pili ana i ke kaʻina hana o ke koko e hoʻololi ana mai ke ʻano kahe i ke ʻano gel, a ʻo kona ʻano maoli ke kaʻina hana o ka hoʻololi ʻana i ka fibrinogen soluble i fibrinogen insoluble i loko o ka plasma. Ma ke ʻano haiki, i ka wā e hōʻino ʻia ai nā kīʻaha koko, hana ke kino i nā mea coagulation, kahi e hoʻāla ʻia e hana i ka thrombin, ka mea e hoʻololi hope ai i ka fibrinogen i fibrin, a laila e paipai ana i ka coagulation koko. ʻO ka coagulation ma ke ʻano laulā e komo pū me ka hana platelet.

ʻO ka hoʻoholo ʻana inā maikaʻi ka coagulation a ʻaʻole paha ma o nā hoʻokolohua koko a me nā hoʻokolohua keʻena hoʻokolohua. ʻO ka hana coagulation dysfunction e pili ana i nā pilikia me nā mea coagulation, ka emi ʻana o ka nui a i ʻole ka hana maʻamau ʻole, a me kahi moʻo o nā hōʻailona koko. Hiki ke loaʻa ke koko koke, a hiki ke ʻike ʻia ka purpura, ecchymosis, epistaxis, nā ʻāʻī koko, a me ka hematuria ma ka ʻili a me nā membrane mucous. Ma hope o ka trauma a i ʻole ke ʻoki ʻana, piʻi ka nui o ke koko a hiki ke hoʻolōʻihi ʻia ka manawa koko. Ma o ka ʻike ʻana i ka manawa prothrombin, ka manawa prothrombin i hoʻāla hapa ʻia a me nā mea ʻē aʻe, ua ʻike ʻia ʻaʻole maikaʻi ka hana coagulation, a pono e wehewehe ʻia ke kumu o ka hōʻailona.