I-TT ibhekisela esikhathini sokujiya kwegazi ngemva kokufaka i-thrombin ejwayelekile ku-plasma. Endleleni evamile yokujiya, i-thrombin ekhiqizwayo iguqula i-fibrinogen ibe yi-fibrin, engabonakaliswa yi-TT. Ngenxa yokuthi imikhiqizo yokujiya kwe-fibrin (proto) (FDP) ingandisa i-TT, abanye abantu basebenzisa i-TT njengesivivinyo sokuhlola uhlelo lwe-fibrinolytic.