Ukwakheka kwe-thrombus kuhlobene nokulimala kwemithambo yegazi, ukujiya kwegazi ngokweqile, kanye nokwehla kokugeleza kwegazi. Ngakho-ke, abantu abanalezi zici ezintathu eziyingozi bathambekele ekuqhumeni kwe-thrombus.

1. Abantu abanokulimala kwe-endothelial yemithambo yegazi, njengalabo abaye babhobozwa imithambo yegazi, bafakwa i-catheter emithanjeni yegazi, njll., ngenxa ye-endothelium yemithambo yegazi eyonakele, imicu ye-collagen evezwe ngaphansi kwe-endothelium ingavuselela ama-platelet kanye nezinto ezibangela ukujiya kwegazi, okungase kuqalise ukujiya kwegazi emithanjeni yegazi. Uhlelo lubangela i-thrombosis.

2. Abantu abanegazi elisesimweni sokujiya kakhulu, njengeziguli ezinezimila ezibulalayo, i-systemic lupus erythematosus, ukulimala okukhulu noma ukuhlinzwa okukhulu, banezici eziningi zokujiya egazini labo futhi banamathuba amaningi okujiya kunegazi elivamile, ngakho-ke banamathuba amaningi okwakha i-thrombosis. Esinye isibonelo ngabantu abathatha izithibela-nzalo, i-estrogen, i-progesterone kanye neminye imithi isikhathi eside, umsebenzi wabo wokujiya kwegazi nawo uzothinteka, futhi kulula ukwakha amahlule egazi.

3. Abantu abageleza igazi labo lincishisiwe, njengalabo abahlala phansi isikhathi eside ukuze badlale i-mahjong, babukele i-TV, batadishe, bathathe isigaba sezomnotho, noma bahlale embhedeni isikhathi eside, ukuntuleka kokuzilolonga ngokomzimba kungabangela ukuthi ukugeleza kwegazi kwehle noma kume. Ukwakheka kwama-vortices kubhubhisa isimo sokugeleza kwegazi esijwayelekile, okuzokwandisa amathuba okuthi ama-platelet, amaseli e-endothelial kanye nezinto ezibangela ukuminyana kwemithambo yegazi zithinteke, futhi kulula ukwakha i-thrombus.