I-FIB yisifinyezo sesiNgisi se-fibrinogen, kanti i-fibrinogen iyisici sokujiya. Ukujiya kwegazi okuphezulu Inani le-FIB lisho ukuthi igazi lisesimweni sokujiya kwegazi okukhulu, futhi i-thrombus yakheka kalula.
Ngemva kokuba indlela yokujiya komuntu isebenze, i-fibrinogen iba yi-fibrin monomer ngaphansi kwesenzo se-thrombin, kanti i-fibrin monomer ingahlangana ibe yi-fibrin polymer, ewusizo ekwakhekeni kwehlule legazi futhi idlala indima ebalulekile enqubweni yokujiya.
I-Fibrinogen ikhiqizwa kakhulu yi-hepatocytes futhi iyiprotheni enomsebenzi wokujiya. Inani layo elijwayelekile liphakathi kuka-2 ~ 4qL. I-Fibrinogen iyisithako esihlobene nokujiya, futhi ukwanda kwayo kuvame ukuba ukusabela okungaqondile komzimba futhi kuyisici esiyingozi sezifo ezihlobene ne-thromboembolism.
Inani le-FIB lokujiya lingakhushulwa ezifweni eziningi, izici ezivamile zofuzo noma ukuvuvukala, amafutha aphezulu egazini, umfutho wegazi
Isifo senhliziyo esiphezulu, esihambisana nemithambo yegazi, isifo sikashukela, isifo sofuba, isifo sezicubu ezixhumeneyo, isifo senhliziyo, kanye nezimila ezinobungozi. Uma unesifo sazo zonke lezi zifo ezingenhla kungabangela ukwenzeka kwamahlule egazi. Ngakho-ke, ukujiya kwegazi okuphezulu Inani le-FIB libhekisela esimweni sokujiya kwegazi okuphezulu.
Izinga eliphezulu le-fibrinogen lisho ukuthi igazi lisesimweni sokujiya kwegazi ngokweqile futhi lithambekele ekushayweni yi-thrombosis. I-Fibrinogen yaziwa nangokuthi i-coagulation factor I. Kungakhathaliseki ukuthi i-endogenous coagulation noma i-exogenous coagulation, isinyathelo sokugcina se-fibrinogen sizovuselela ama-fibroblast. Amaprotheni ahlanganiswa kancane kancane kunethiwekhi ukuze akhe ama-blood clots, ngakho-ke i-fibrinogen imelela ukusebenza kwe-blood coagulation.
I-Fibrinogen ikhiqizwa kakhulu yisibindi futhi ingakhushulwa ezifweni eziningi. Izici ezivamile zofuzo noma ukuvuvukala zifaka phakathi amafutha aphezulu egazini, umfutho wegazi ophakeme, isifo senhliziyo, isifo sikashukela, isifo sofuba, isifo sezicubu ezixhumeneyo, isifo senhliziyo, kanye nezimila ezinobungozi zizokhuphuka. Ngemva kokuhlinzwa okukhulu, ngoba umzimba udinga ukwenza umsebenzi we-hemostasis, uzophinde ukhuthaze ukwanda kwe-fibrinogen ukuze umsebenzi we-hemostasis usebenze.
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