I-APTT isifinyezo sesiNgisi sesikhathi se-prothrombin esisebenza kancane. I-APTT ukuhlolwa kokuhlola okubonisa indlela yokugoba kwegazi e-endogenous. I-APTT ende ikhombisa ukuthi isici esithile sokugoba kwegazi esihilelekile endleleni yokugoba kwegazi endogenous yomuntu asisebenzi kahle. Ngemva kokuba i-APTT ithathe isikhathi eside, isiguli sizoba nezimpawu zokopha ezisobala. Isibonelo, iziguli ezine-hemophilia A, i-hemophilia B, kanye nesifo se-von Willebrand zonke zizoba ne-APTT ende, kanti isiguli sizoba ne-ecchymosis esikhumbeni nasezingxeni zolwelwesi, kanye nokopha kwemisipha. , ukopha kwamalunga, i-hematoma, njll. Ikakhulukazi ezigulini ezine-hemophilia A, ukukhubazeka kwamalunga kanye nokuwohloka kwemisipha kuvame ukushiywa ngemuva kokuba i-hematoma imuncwe ngenxa ye-synovitis ebangelwa ukopha kwamalunga, okunomthelela omkhulu empilweni. Ngaphezu kwalokho, ukugoba kwegazi okusabalele ngaphakathi kwemithambo yegazi, isifo sesibindi esibi kanye nezinye izifo nakho kuzobangela ukwanda okukhulu kwe-APTT, okuzobangela umonakalo osobala emzimbeni womuntu.
Inani eliphezulu le-Aptt libonisa ukuthi isiguli singase sibe nezinkinga zokopha. Izinkinga zokopha ezivamile zifaka phakathi ukuntuleka kwe-congenital coagulation factor kanye ne-hemophilia. Okwesibili, kusolwa ukuthi kubangelwa yisifo sesibindi noma i-obstructive jaundice noma isifo se-thrombotic. Akukacaci futhi ukuthi kubangelwa yithonya lezinto ezisetshenziswa emithini, njengokusetshenziswa isikhathi eside kwemithi elwa nokuvuvukala kwegazi. Ngokwezokwelapha, ukuhlolwa kwe-aptt kungasetshenziswa ukwahlulela ukuthi umsebenzi wokuqina kwegazi emzimbeni wesiguli ujwayelekile yini. Uma kungenxa yesimo esibangelwa yi-hemophilia, kunconywa ukulandela iseluleko sikadokotela sokuyeka ukopha noma ukusebenzisa ukwelashwa okuyinkimbinkimbi kwe-prothrombin.