Isizathu se-thrombosis sihlanganisa ama-lipid amaningi egazini, kodwa akuwona wonke ama-clot egazi abangelwa ama-lipid amaningi egazini. Okusho ukuthi, imbangela ye-thrombosis ayibangelwa ukuqongelela kwezinto zamafutha kanye ne-viscosity ephezulu yegazi. Esinye isici esiyingozi ukuhlangana ngokweqile kwama-platelet, amaseli okujiya kwegazi emzimbeni. Ngakho-ke uma sifuna ukuqonda ukuthi i-thrombus yakheka kanjani, sidinga ukuqonda ukuthi kungani ama-platelet ehlangana?
Ngokuvamile, umsebenzi oyinhloko wama-platelet ukujiya. Lapho isikhumba sethu silimele, kungase kube nokopha ngalesi sikhathi. Isibonakaliso sokopha sizodluliselwa ohlelweni oluphakathi. Ngalesi sikhathi, ama-platelet azobuthana endaweni yenxeba futhi aqhubeke nokuqongelela enxebeni, ngaleyo ndlela avimbe ama-capillary futhi afeze injongo ye-hemostasis. Ngemva kokulimala, kungase kwakheke ama-scabs egazi enxebeni, empeleni akhiwa ngemva kokuhlanganiswa kwama-platelet.
Uma lesi simo esingenhla senzeka emithanjeni yethu yegazi, kuvame kakhulu ukuthi imithambo yegazi yemithambo yonakale. Ngalesi sikhathi, ama-platelet azobuthana endaweni eyonakele ukuze kufezwe injongo ye-hemostasis. Ngalesi sikhathi, umkhiqizo wokuhlanganiswa kwama-platelet akusiwo uqweqwe lwegazi, kodwa yi-thrombus esikhuluma ngayo namuhla. Ngakho-ke ingabe i-thrombosis emthanjeni wegazi ibangelwa ukulimala komthambo wegazi? Ngokuvamile, i-thrombus empeleni yakhiwa ukuqhekeka komthambo wegazi, kodwa akuyona indaba yokuqhekeka komthambo wegazi, kodwa ukulimala kodonga lwangaphakathi lomthambo wegazi.
Kuma-plaque e-atherosclerotic, uma kwenzeka ukuqhekeka, amafutha abekwe ngalesi sikhathi angase abonakale egazini. Ngale ndlela, ama-platelet egazini ayadonseka. Ngemva kokuba ama-platelet ethole isignali, azoqhubeka nokuhlangana lapha futhi ekugcineni akhe i-thrombus.
Kalula nje, ama-lipid aphezulu egazini akuyona imbangela eqondile ye-thrombosis. I-Hyperlipidemia iwukuthi nje kukhona ama-lipid amaningi emithanjeni yegazi, futhi ama-lipid awahlangani abe amaqoqo emithanjeni yegazi. Kodwa-ke, uma izinga lama-lipid egazini liqhubeka nokukhuphuka, kungenzeka kakhulu ukuthi i-atherosclerosis kanye ne-plaque kuzovela. Ngemva kokuba lezi zinkinga zenzekile, kungase kube nomcimbi wokuqhekeka, futhi i-thrombus kulula ukuyidala ngalesi sikhathi.
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