Inqubo ye-Thrombosis, ehlanganisa izinqubo ezimbili:

1. Ukunamathela nokuhlanganiswa kwama-platelet egazini

Esigabeni sokuqala se-thrombosis, ama-platelet aqhubeka ephuma ekugelezeni kwe-axial futhi anamathele ebusweni bezintambo ze-collagen eziveziwe eduze kwemithambo yegazi eyonakele. Ama-platelet asebenza yi-collagen futhi akhipha izinto ezifana ne-ADP, i-thromboxane A2, i-5-AT kanye ne-platelet factor IV. Lezi zinto zinomthelela omkhulu wokuhlanganisa ama-platelet, ukuze ama-platelet egazini aqhubeke nokuhlangana endaweni ukuze akhe inqwaba yama-platelet efana ne-mound. , ukuqala kwe-venous thrombosis, ikhanda le-thrombus.

Ama-platelet anamathela ebusweni bemicu ye-collagen eveziwe eduze komthambo wegazi owonakele futhi ayasebenza ukuze akhe i-platelet efana ne-hillock. I-hillock iyanda kancane kancane futhi ixubana nama-leukocyte ukuze yakhe i-white thrombus. Inama-leukocyte amaningi anamathele ebusweni bayo. Ukugeleza kwegazi kuyehla kancane kancane, uhlelo lokujiya luyasebenza, futhi inani elikhulu le-fibrin lakha isakhiwo senethiwekhi, esibamba amaseli egazi abomvu engeziwe namaseli egazi amhlophe ukuze akhe i-thrombus exubile.

2. Ukujiya kwegazi

Ngemva kokwakheka kwe-thrombus emhlophe, iphuma iye ku-lumen yemithambo yegazi, okwenza ukugeleza kwegazi ngemuva kwayo kwehle futhi kubonakale sengathi yi-whirlpool, bese kwakheka i-platelet mound entsha ku-whirlpool. Ama-Trabeculae, akhiwe njenge-coral, anama-leukocyte amaningi anamathele ebusweni bawo.

Ukugeleza kwegazi phakathi kwe-trabeculae kunciphisa kancane kancane, uhlelo lokujiya luyasebenza, futhi ukuhlushwa kwezinto zojiya zendawo kanye nezinto zojiya kuyanda kancane kancane, okwenza futhi kuhlangane kube yisakhiwo se-mesh phakathi kwe-trabeculae. I-thrombus emhlophe nemhlophe, ehlanganisiwe eyakha umzimba we-thrombus.

I-thrombus exubile yanda kancane kancane futhi yanda ngendlela igazi eligeleza ngayo, futhi ekugcineni yavimba ngokuphelele i-lumen yemithambo yegazi, okwenza ukugeleza kwegazi kume.