Uma umsebenzi wesiguli wokujiya kwegazi uholela ekuphumeni kwegazi, kungase kubangelwe ukwehla komsebenzi wokujiya kwegazi. Kudingeka ukuhlolwa kwezinto ezijiya igazi. Kusobala ukuthi ukuphuma kwegazi kubangelwa ukuntuleka kwezinto ezijiya igazi noma ezinye izinto ezivimbela ukujiya kwegazi. Ngokusho kwembangela, engeza izinto ezijiya igazi noma i-plasma entsha. Ukuba khona kwezinto ezijiya igazi kungasiza ekumiseni ukopha. Ngokwezokwelapha, kungatholakala ukuthi izinto ezijiya igazi ezihambisanayo zezindlela zangaphakathi nezangaphandle zokujiya kwegazi zinciphile noma zingasebenzi kahle, futhi uhlole ukuthi umsebenzi wokujiya igazi ongavamile ubangelwa ukuntuleka kwezinto ezijiya igazi noma umsebenzi wezinto ezijiya igazi, ikakhulukazi okuhlanganisa lezi zimo ezilandelayo:

1. Indlela yokujiya kwe-endogenous engajwayelekile: Isici esiyinhloko sokujiya esithinta indlela yokujiya kwe-endogenous yi-APTT. Uma i-APTT iqhubeka isikhathi eside, kusho ukuthi kunezici zokujiya ezingavamile endleleni ye-endogenous, njengesici 12, isici 9, isici 8, kanye nendlela evamile 10. Ukuntuleka kwesici kungabangela izimpawu zokopha ezigulini;

2. Indlela yokujiya kwe-extrinsic engajwayelekile: uma i-PT iqhubeka isikhathi eside, kungatholakala ukuthi i-tissue factor, i-factor 5 kanye ne-factor 10 endleleni evamile konke kungase kungavamile, okungukuthi, ukwehla kwenani kuholela esikhathini sokujiya isikhathi eside futhi kubangele ukopha esigulini.